中国当代医药2019，Vol.26Issue(11)：21-25,5.
NSCLC患者耐药基因检测对临床治疗效果的影响研究
Study on the influence of drug resistance gene detection in NSCLC patients on clinical therapeutic effect
刘浩锋 1丁少波 1吴雪婷 1郑锐年2
作者信息
- 1. 广东省东莞市人民医院临床药学科,广东 东莞 523000
- 2. 广东省东莞市人民医院肿瘤内科,广东 东莞 523000
- 折叠
摘要
Abstract
Objective To explore the influence of drug resistance gene detection in patients with non-small cell lung cancer (NSCLC) on clinical therapeutic efficacy. Methods A total of 120 NSCLC patients who received treatment in our hospital from March 2016 to March 2017 were selected. Multidrug resistance gene (MDR1), human epidermal growth factor receptor-2 gene (c-erbb-2), glutathione S transferase (GST-π) were detected by immunohistochemical S-P method. The patients were treated with Cisplatin, Vincristine and Vinblastine Amide, and the tumor inhibition rates of patients with positive expression of three drug resistance genes were detected. Results The positive expression rates of MDR1, c-erbB-2 and GST-π were lower than those of negative expression (P<0.05). The positive expression rates of MDR1, c-erbB-2 and GST-π genes in NSCLC patients were not related to sex and age, but which were related to pathological stage, pathological type, lymph node metastasis, infiltration degree and differentiation degree (P<0.05). The tumor inhibition rates of MDR1 and c-erbB-2 positive expression were lower than those of GST-π positive expression (P<0.05). Conclusion Detection of drug resistance genes in NSCLC patients can diagnose drug resistance of patients and effectively improve the treatment effect and prognosis of patients.关键词
非小细胞肺癌/耐药基因/多药耐药基因/人类表皮生长因子受体-2基因/谷胱苷肽-S-转移酶Key words
Non-small cell lung cancer/Drug resistance gene/Multidrug resistance gene/Human epidermal growth factor receptor-2 gene/Glutathione-S-transferase分类
医药卫生引用本文复制引用
刘浩锋,丁少波,吴雪婷,郑锐年..NSCLC患者耐药基因检测对临床治疗效果的影响研究[J].中国当代医药,2019,26(11):21-25,5.
