摘要
Abstract
Objective To understand and analyze the characteristics of neonatal bacterial culture positivity and drug sensitivity test, antibacterial drug treatment and prognosis in our hospital, so as to provide reference for clinical diagnosis, initial treatment and antibacterial selection. Methods The clinical data of anti-infective treatment of 36 cases of bacterial culture-positive children discharged from the neonatology department of Inner Mongolia Autonomous Region Maternal and Child Health Hospital from January to June 2018 were retrospectively analyzed. Results A total of 41 strains of pathogenic bacteria were cultured in 36 children, mainly with Gram-negative bacteria (G-bacteria) accounting for 61.0％, and most of them were Enterobacter cloacae accounting for 29.3％. The results of drug sensitivity test showed that G-bacteria had higher sensitivity to Cefepime, Piperacillin Tazobactam Sodium, Imipenem, Gentamicin, Amikacin, Tobramycin and Nitrofurantoin. Gram -positive bacteria (G +bacteria) were in high sensitivity with Vancomycin, Quinupristin, Linezolid, Nitrofurantoin, and Rifampicin. Most children were treated with sensitive drugs and their symptoms were improved or cured. Conclusion Currently, neonatal infection in our hospital is still dominated by G-bacteria including Enterobacter cloacae and Klebsiella pneumoniae. Before the completion of the pathogen examination, empirical treatment should be given based on the symptoms of the children, the maternal condition and the bacterial resistance monitoring in our hospital. After obtaining the drug sensitivity report, precise treatment should be applied after accurate assessment of the drug use, symptoms and signs of the children with the consideration of drug change.关键词
新生儿/感染/药敏试验/抗菌药物Key words
Neonate/Infection/Drug sensitivity test/Antibacterial drugs分类
医药卫生
