中国健康心理学杂志2019，Vol.27Issue(1)：4-6,3.DOI:10.13342/j.cnki.cjhp.2019.01.002
同型半胱氨酸、叶酸、维生素B12与阿尔茨海默病精神行为症状的相关性
Correlation between homocysteine, folic acid, vitamin B12 and behaviral and psychological symptoms of alzheimer's disease
摘要
Abstract
Objective:To explore the relationship between behavioral and psychological symptoms of dementia and plasma homocysteine, folic acid and vitamin B12.Methods:A total of 40 alzheimer disease (AD) patients with BPSD, 39 AD patients without BPSD, and 39 healthy controls were recruited in the study.All participants were tested the level of Hcy, folic acid, vitamin B12 and were assessed clinical symptoms and cognitive function.Results:The levels of plasma Hcy, folic acid and vitamin B12 in the 3 groups were different, and the difference was statistically significant (F=14.76, 57.53, 88.84;P<0.01).The level of Hcy in the two AD groups of patients were higher than that of normal control group;folic acid and VitB12in the two AD groups were lower than that of the normal control group (t=2.53, 5.36, -8.68, -10.91, -13.39, -8.54;P<0.01).The level of Hcy in group BPSD was higher than that in non BPSD group, but the level of VitB12 was low, and the difference was statistically significant (t=2.92, -4.28, P<0.01).In the two patients, the cognitive function was negatively correlated with the level of Hcy (r=-0.602;P<0.05), and was positively correlated with the level of vitamin B12 (r=0.225;P<0.05).Conclusion:Hcy, folic acid and vitamin B12 are associated with AD.Hcy and vitamin B12may take part in the pathogenesis of BPSD in AD.关键词
阿尔茨海默病/精神行为症状/同型半胱氨酸/叶酸/维生素B12/认知功能Key words
Alzheimer's disease/Behavioral and psychological symptoms/Homocysteine/Folic acid/Vitamin B12/Cognitive function分类
医药卫生引用本文复制引用
汪周兵,张碧丹,郭云霞,张丹伟,张广华,张长春..同型半胱氨酸、叶酸、维生素B12与阿尔茨海默病精神行为症状的相关性[J].中国健康心理学杂志,2019,27(1):4-6,3.基金项目
镇江市卫生科技重点专项基金资助项目(编号:SHW2015011) （编号:SHW2015011）
江苏大学医学临床科技发展基金资助项目(编号:JLY20140032) （编号:JLY20140032）
镇江市社会发展指导性项目立项课题(编号:FZ2015046) （编号:FZ2015046）
