中国健康心理学杂志2019，Vol.27Issue(2)：169-173,5.DOI:10.13342/j.cnki.cjhp.2019.02.003
围绝经期抑郁发作患者治疗前后甲状腺激素水平
Thyroid hormone levels before and after treatment of perimenopausal depressed patients
摘要
Abstract
Objective:To explore the changes of blood thyroxine before and after treatment in perimenopausal depressed patients and study the correlations in anxiety, depression, symptoms and thyroid hormone levels.Methods:We recruited 133 perimenopausal depressed patients (34 cases lost) with Hamilton Depression Scale-24 (HAMD-24) score≥20 points to take oral Escitalopram.The HAMD-24, HAMA-14 and thyroid hormone were assessed at the 4 th and 8 th week of treatment.A self-controlled study was conducted to compare the changes of depressive symptoms and analyze their correlation with thyroid hormone levels before and after treatment.Results:The scores of HAMD-24 and HAMA-14 were all significantly lower at 4 th and 8 th week than those at baseline (F=1354.384, 92.021;P<0.01) .The serum level of FT4 was decrease with time (F=10.275, P<0.001) , and had significant difference between the baseline and 4 th, 8 th (P<0.001) .FT4 was significantly positively related to HAMD-24 scores, anxiety/somatization factor, HAMA-14 total score and physical anxiety factor (r=0.135, 0.312, 0.362, 0.320, 0.360;P<0.01) , and significantly negatively related to the HAMD-24 weight factor (r=-0.281, P<0.01) .Conclusion:There are significant correlations between the anxiety and depressive symptoms of perimenopausal depressed patients and the serum level of FT4.关键词
围绝经期/抑郁发作/甲状腺激素/艾司西酞普兰Key words
Perimenopause/Depressive episode/Thyroid hormone/Escitalopram分类
医药卫生引用本文复制引用
王体宾,孔德荣,李猛,阎琳,霍军,刘小俊,刘文文,闫翌君,魏宏强,李爱玲..围绝经期抑郁发作患者治疗前后甲状腺激素水平[J].中国健康心理学杂志,2019,27(2):169-173,5.基金项目
河南省郑州市科技攻关项目(编号:153PKJGG079) （编号:153PKJGG079）
