中国健康心理学杂志2019，Vol.27Issue(3)：351-355,5.DOI:10.13342/j.cnki.cjhp.2019.03.009
围绝经期伴焦虑特征抑郁发作患者甲状腺激素水平
The thyroid hormone level of perimenopausal depressed patients with anxious characteristics
摘要
Abstract
Objective:To explore the thyroid hormone levels of perimenopausal depressed patients with anxious characteristics before and after treatment, and further analyze the relationship of anxious symptoms with thyroid hormone levels.Methods:Perimenopausal depressed patients with Hamilton Depression Scale-24 (HAMD-24) score≥20were recruited, HAMA-14was used to assess anxiety level, and patients with anxious characteristics was defined as HAMA-14score＞7.Health subjects with age and education matched were also recruited.Patients were treated with oral escitalopram for 8weeks and clinical symptoms were assessed at the baseline, 4th and 8th week of treatment.Results:A total of 113patients enrolled finally in the study were divided into anxiety group (81patients, 19cases lost) and without anxiety group (52patients, 15cases lost) , and 40health subjects were recruited.There were significant differences on the serum levels of FT4within the group (F=5.668, P＜0.01) , among three groups (F=4.917, P＜0.01) and group×time interaction effect (F=3.685, P＜0.01) .The serum level of FT4of depressed patients with anxiety symptoms at baseline was significantly higher than those without anxious symptoms (t=3.004, P＜0.01) .The serum level of FT4decreased gradually among depressed patients both with and without anxiety symptoms after the treatment, and there were significant differences on serum level of FT4at each time point in anxiety group (F=14.736, P＜0.001) .There were significant differences on serum level of TSH at baseline among three groups (P=0.003) , and the serum level of TSH was significantly lower in the anxiety group than that in the health group (t=-2.600, P＜0.05) .There was no statistical significance on within-subjects effects and the group×time interaction effect (P＞0.05) .Serum levels of FT4and body mass factor scores were all negatively correlated at baseline, 4th and 8th week of treatment (P＜0.05) .In the anxiety group, there were negative correlation between the serum level of FT4and weight factor of HAMD-14at baseline, 4th and 8th week of treatment (P＜0.05) ;there were positive correlations between the serum level of FT4and total score of HAMA-14, somatic anxiety, mental anxiety at baseline, 4th and 8th week respectively (P＜0.05) .Conclusion:There are significant correlations between anxiety symptoms of perimenopausal depressed patients and the serum level of FT4.It may be a potential way for improving anxiety symptoms to regulate thyroid hormone levels.关键词
围绝经期/抑郁发作/焦虑/甲状腺激素/艾司西酞普兰Key words
Perimenopause/Major depressive disorder/Anxiety/Thyroid hormone/Escitalopram分类
医药卫生引用本文复制引用
李猛,孔庆梅,孔德荣,司天梅,霍军,刘小俊,王丽,阎琳,刘文文,王体宾,闫翌君,魏宏强..围绝经期伴焦虑特征抑郁发作患者甲状腺激素水平[J].中国健康心理学杂志,2019,27(3):351-355,5.基金项目
郑州市科技攻关项目(编号:153PKJGG079) （编号:153PKJGG079）
