解剖学杂志(社会科学版)2019，Vol.42Issue(2)：125-127,3.DOI:10.3969/j.issn.1001-1633.2019.02.004
不同年龄人肝解偶联蛋白2表达与衰老的关系
Relationship between expression of uncoupling protein 2 and aging in human liver at different ages
摘要
Abstract
Objective:To explore the expression of uncoupling protein 2(UCP2)in human liver tissues and its relationship with aging.Methods:Clinical human liver tissues were selected and divided into fetal group,adult group and elderly group according to ages.The content of malondialdehyde(MDA)and glutathione(GSH),adenosine triphosphate(ATP)were determined from each group.The expression and distribution of UCP2 were studied in liver tissues by immunohistochemistry.Results:MDA of the elderly group was higher than that of the fetal group and the adult group.The GSH content in the elderly group was lower than that in the fetal group and the adult group.The ATP level was lower in the elderly group than that in the fetal group and the adult group.UCP2 protein was expressed more in the liver cells of the elderly group,and was less expressed(or even not expressed)in the liver cells of the fetal group and the adult group.Conclusion:The MDA content increases and the GSH content decreases in the liver tissue of the elderly,suggesting the increased level of reactive oxygen species(ROS)in the liver tissue of the elderly results in the increased expression of UCP2.UCP2 plays an important role in the process of the damage and aging in liver cells.关键词
解偶联蛋白2/肝/活性氧/衰老Key words
uncoupling protein 2/liver/reactive oxygen/aging引用本文复制引用
胡祥上,宫德正,蒋建国,韩伟,蔡世昌,陈峡,于鹏辉,邹原..不同年龄人肝解偶联蛋白2表达与衰老的关系[J].解剖学杂志(社会科学版),2019,42(2):125-127,3.基金项目
湖南省教育厅科研项目(11C1010) （11C1010）
