解放军医学院学报2018，Vol.39Issue(12)：1097-1101,5.DOI:10.3969/j.issn.2095-5227.2018.12.017
KRAS突变阳性的结直肠癌患者体细胞突变分析
Tumor-related somatic mutation in KRAS-mutated colorectal cancer
董周寰 1石怀银 1吕亚莉 1钟梅 1朱凤伟1
作者信息
- 1. 解放军总医院 病理科,北京 100853
- 折叠
摘要
Abstract
Objective To analyze the characteristics of KRAS as well as other tumor-related gene mutation in colorectal cancer patients, and provide evidences for treatment and prognosis of these patients.Methods Totally 50 colorectal cancer patients with KRAS exon 2 G12/13 mutation admitted to our hospital from January 2015 to June 2016 were enrolled in this study.Next-generation sequencing (NGS) technology was used to detect the hot spot mutations of 59 tumor-related genes in FFPE samples.Results Totally65 mutations in 12 genes were detected except KRAS.The abundance of mutations was over 10％in TP53 (62％) , APC (46％) , PIK3CA (22％) and SMAD4 (14％) .The mutation frequency or hotspot distribution of these genes was associated with the growth of colorectal tumors.Conclusion TP53, APC, PIK3CA, SMAD4 may be related to KRAS gene and its pathway in colorectal cancer.关键词
结直肠癌/KRAS基因/二代测序/体细胞突变Key words
colorectal cancer/KRAS gene/next-generation sequencing/somatic mutation分类
医药卫生引用本文复制引用
董周寰,石怀银,吕亚莉,钟梅,朱凤伟..KRAS突变阳性的结直肠癌患者体细胞突变分析[J].解放军医学院学报,2018,39(12):1097-1101,5.
