检验医学与临床2019，Vol.16Issue(3)：292-294,298,4.DOI:10.3969/j.issn.1672-9455.2019.03.002
不同血压分级2型糖尿病患者血清鸢尾素与左心结构、功能的关系
Change of serum Irisin and its correlation with left cardiac structure and function in type 2 diabetes patients with different grades of blood pressure
摘要
Abstract
Objective To study the change of serum Irisin and its correlation with left cardiac structure and function in type 2 diabetes mellitus (T2DM) patients with different grades of blood pressure.Methods One hundred and twenty-five inpatients with T2DM complicating hypertension (diabetes complicating hypertension group) in the endocrinology department of the Baoding Municipal First Central Hospital, 40 cases of simple T2DM (DS group) and contemporaneous 35 individuals undergoing healthy physical examination (NS group) were collected.The levels of serum Irisin was detected, and the echocardiographic parameters were examined.The differences of various indexes among the subjects were compared and their correlation was analyzed.Results Compared with the NS group, the levels of IVST, LVEDD, LVPWT, LAD and LVMI in the DS group were significantly increased and the levels of LVEF, E/A and Irisin were significantly decreased (P<0.05) .Among them, the levels of IVST, LVPWT and LVMI in the hypertension grade 3 group were the highest, and the levels of LVEF and Irisin were the lowest.LVEDD was increased with the rise of pressure grade, and E/A was decreased.The regression analysis results showed that LVEF had the correlation with Irisin expression (P<0.05) .Conclusion The left heart hypertrophic degree in the patients with T2DM is correspondingly increased along with the rise of blood pressure grade, while the left systolic function is also decreased and serum Irisin level is lowered.Irisin might participate in the change of left cardiac structure and function in the patients with T2DM complicating hypertension.关键词
2型糖尿病/高血压/鸢尾素Key words
type 2 diabetes mellitus/hypertension/Irisin分类
医药卫生引用本文复制引用
张鑫,李宝新,张云良,常文龙,王翯,马爽,郭淑芹..不同血压分级2型糖尿病患者血清鸢尾素与左心结构、功能的关系[J].检验医学与临床,2019,16(3):292-294,298,4.基金项目
国家自然科学基金资助项目(81500644) （81500644）
河北省医学科学研究重点课题计划(20160282) （20160282）
河北省保定市科学技术研究与发展指导计划(17ZF036). （17ZF036）
