检验医学与临床2019，Vol.16Issue(3)：299-302,4.DOI:10.3969/j.issn.1672-9455.2019.03.004
罗格列酮对哮喘小鼠肺组织GABAARα、MUC5AC表达的影响
Effects of rosiglitazone on expression of GABAARαand MUC5AC in lung tissues of asthmatic mice
摘要
Abstract
Objective To preliminarily invetigate the relation among rosiglitazone, GABAARα and MUC5AC by observing the expression level change of lung tissue GABAARαand MUC5AC in asthmatic mice before and after the intervention in order to provide a theoretical basis for the early intervention treatment of asthma.Methods One hundred female BABL/C mice, 6-8 weeks old, were randomly divided into 5 groups, control group, asthma model group, dexamethasone group, rosiglitazone group and dexamethasone plus rosiglitazone group, 20 cases in each group.After last time excitation, the mouse blood and lung tissue were taken for conducting the related detection.Results The lung tissue HE staining showed that the lung tissue inflammatory cell infiltration degree in the rosiglitazone and dexamethasone groups was significantly reduced compared with the asthma model group;serum IL-4 and eotaxin-1 levels in the rosiglitazone group and dexamethasone group were significantly lower than those in the asthma model group and higher than those in the control group (P<0.05) ;the expression levels of GABAARαand MUC5AC protein in the rosiglitazone group were lower than those in the dexamethasone group, and higher than those in the dexamethasone plus rosiglitazone group (P<0.05) .Conclusion Rosiglitazone may decrease serum IL-4 and Eotaxin-1 levels in asthmatic mice, as well as reduce the excessive secretion of airway mucus and relieve the severity of acute asthma attacks by downregulating the expression of GABAARαand MUC5AC protein.关键词
哮喘/罗格列酮/GABAARα/MUC5ACKey words
asthma/rosiglitazone/GABAARα/MUC5AC分类
医药卫生引用本文复制引用
吴艳梅,张栓宝,吕建宁,张莉莉,柴雅琴,薛智文,杜小梅,张卓红,张治国,张引亮..罗格列酮对哮喘小鼠肺组织GABAARα、MUC5AC表达的影响[J].检验医学与临床,2019,16(3):299-302,4.基金项目
陕西省2017年重点研发计划项目(2017SF-068). （2017SF-068）
