检验医学与临床2019，Vol.16Issue(3)：312-315,4.DOI:10.3969/j.issn.1672-9455.2019.03.008
不同手术方式治疗学龄前儿童OSAHS术前及术后免疫功能的比较
Comparison of preoperative and postoperative immune function in preschool children with OSAHS treated by different surgical modes
摘要
Abstract
Objective To explore the most suitable surgical modes for children with obstructive sleep apnea hypopnea syndrome (OSAHS) by comparing the preoperative and postoperative immune function of OSAHS children treated by different surgical methods in order to maximize to improve their life quality without affecting their immunity.Methods A total of 120 children aged 3-6 years old were selected.OSAHS was diagnosed by polysomnography (PSG) .They were randomly divided into the velopharyngeal angioplasty group and partial tonsillectomy group.Serum immunoglobulin IgA, IgG, IgM, complement C3, C4 levels and T lymphocyte subsets CD3+, CD4+, CD8+, CD4+/CD8+ ratio and NK value were measured before operation and at postoperative one and three months.Meanwhile the blank control group was established.The same indexes were monitored.The data before operation and at postoperative one and three months in the two experimental groups were statistically analyzed.Results At postoperative one month, the levels of IgA, IgG, IgM, complement C3 and C4 in the two experimental groups were decreased compared with those on preoperative one d, but the difference was not statistically significant (P>0.05) , which at postoperative three months were closed to the preoperative levels.In the comparison between the partial tonsillectomy group and velopharyngeal angioplasty group, the percentages of CD3+T lymphocytes and CD4+T lymphocytes and NK cells, and ratio of CD4+/CD8+ in the velopharyngeal formation group were significantly lower than those in the partial tonsillectomy group, and the difference was statistically significant (P<0.05) ;postoperative 3 months, the percentages of CD3+T lymphocytes, CD4+T lymphocytes, NK cells and CD4+/CD8+ratio in the velopharyngeal formation group were lower than those in the partial tonsillectomy group, but the difference was not statistically significant (P>0.05) .Conclusion In OSAHS children patients treated by velopharyngeal angioplasty and partial tonsillectomy, the postoperative humoral immunity and cellular immune function are slightly decreased compared with those before surgery, but which basically returns to normal within 3 months.The effects of velopharyngeal angioplasty and partial tonsillectomy on their immune function in the corresponding period have no significant difference.关键词
免疫球蛋白/儿童睡眠呼吸暂停/手术治疗/免疫功能Key words
immunoglobulin/children sleep apnea/surgery treatment/immune function分类
医药卫生引用本文复制引用
张峰,姚红兵,杨大志,苏述平,付航,吕霆..不同手术方式治疗学龄前儿童OSAHS术前及术后免疫功能的比较[J].检验医学与临床,2019,16(3):312-315,4.基金项目
重庆市卫生和计划生育委员会医学科研资助项目(2015MSXM110). （2015MSXM110）
