检验医学与临床2019，Vol.16Issue(3)：335-338,4.DOI:10.3969/j.issn.1672-9455.2019.03.014
美洲大蠊提取物对肝硬化门静脉高压症大鼠VEGF的影响
Effect of APA on VEGF in rats with portal hypertension
摘要
Abstract
Objective To investigate the effects of extract of Periplaneta americana (APA) on the vascular endothelial growth factor (VEGF) in rats with portal hypertension.Methods The rat portal hypertension models was prepared by adopting CCl4 and alcohol.After 9 weeks, and the portal vein pressure in each group was measured by using the direct manometric method.The expression level of VEGF in gastric tissue was detected by immunohistochemistry, and the liver tissue morphology changes were observed.Results The portal vein pressure of the model group was significantly increased compared with the normal group (P<0.01) , the venous pressure in the APA group and propranolol group was significantly increased compared with the normal group (P<0.01) , but was significantly decreased compared with the model group (P<0.01) ;the expression of gastic tissue VEGF in the APA1 and APA2 groups was decreased, moreover the pathological morphology of injured liver was significantly improved.Conclusion The APA not only can improve the hyperdynamic status of portal system, its treatment effect is superior to that of propranolol, moreover reduces the VEGF expression in gastric tissue and improves the pathomorphism of injured liver, its role in treating portal hypertension of liver cirrhosis deserves further study.关键词
美洲大蠊提取物/心得安/门静脉高压/血管内皮生长因子Key words
extract of Periplaneta americana/propranolol/portal hypertension/vascular endothelial growth factor分类
中医学引用本文复制引用
黄宗林,黄应武,王大东,罗显克,王保健,吴晓莉,农云翠,沈海容..美洲大蠊提取物对肝硬化门静脉高压症大鼠VEGF的影响[J].检验医学与临床,2019,16(3):335-338,4.基金项目
广西医科大学青年科学资金项目(GXMUYSF201540). （GXMUYSF201540）
