检验医学与临床2019，Vol.16Issue(3)：364-366,3.DOI:10.3969/j.issn.1672-9455.2019.03.022
过敏性紫癜患儿的免疫功能变化及临床意义
Immune function change and clinical significance in children patients with with Henoch-Schonlein purpura
刘梅 1王军 2孙红 2袁纯辉 2胡玉海 1向贇2
作者信息
- 1. 湖北省武汉市汉口医院检验科,430015
- 2. 华中科技大学同济医学院附属武汉儿童医院检验部,武汉 430015
- 折叠
摘要
Abstract
Objective To investigate the immunological pathogenesis and clinical significance of child Henoch-Schonlein purpura (HSP) by detecting the changes of immune cells, immunoglobulin and complement in peripheral blood.Methods Two hundred and eighty childred cases of definitely diagnosed HSP treated in the hospital from September 2017 to April 2018 were collected, meanwhile 50 children of the same age undergoing healthy physical examination were also collected as the healthy control group.The changes of T lymphocyte subsets, B lymphocytes and NK cells were detected by adopting the flow cytometry assay.The levels of immunoglobulin IgA, IgG, IgM, IgE, complement C3 and C4 were detected by adopting the velocity scatter turbidimetry.Results Compared with the healthy control group, the number of T lymphocytes CD3+, CD4+, CD8+ and CD16+CD56+NK cells in the HSP children patients were decreased significantly (P<0.05) , while there were no different change in the number of CD19+lymphocytes (P>0.05) .But the proportion of CD19+lymphocytes subsets was increased significantly (P<0.05) , the proportion of CD16+CD56+NK cells was decreased significantly (P<0.05) .The eproportions of other lymphocytes had no different changes (P>0.05) .The levels of immunoglobulin IgA, IgG, IgM, IgE and immunoglobulin C3 were significantly increased (P<0.05) , and complement C4 had no statistically significant difference (P>0.05) .Conclusion Children patients with Henoch-Schonlein purpura have immune dysfunction, which is manifested by cellular immunity and NK cells mediated innate immune function downregulation.关键词
过敏性紫癜/儿童/免疫功能/淋巴细胞Key words
Henoch-Schonlein purpura/children/immune function/lymphocytes分类
临床医学引用本文复制引用
刘梅,王军,孙红,袁纯辉,胡玉海,向贇..过敏性紫癜患儿的免疫功能变化及临床意义[J].检验医学与临床,2019,16(3):364-366,3.
