检验医学与临床2019，Vol.16Issue(4)：438-440,3.DOI:10.3969/j.issn.1672-9455.2019.04.002
鲍曼不动杆菌主动外排系统adeR基因分布及耐药性分析
Active efflux system gene adeR distribution of Acinetobacter baumannii and drug resistance analysis
摘要
Abstract
Objective To preliminarily investigate the effect of efflux pumps on the drug resistance of Acinetobacter baumannii by detecting the distribution of the efflux pump gene adeR in Acinetobacter baumannii and its susceptibility situation to clinically commonly used antibacterial drugs.Methods PCR was used to detect the distribution of adeR gene in 84strains of Acinetobacter baumannii, the strains were divided into the adeR gene positive group and adeR gene negative group according to the PCR detection results.The resistance rates to amikacin, cefepime, levofloxacin and imipenem were compared between the two groups of Acinetobacter baumannii.Results The PCR results showed that the adeR gene positive rate in collected Acinetobacter baumannii was 70.24％ (59/84).The resistance rates of the adeR gene positive group to amikacin, cefepime, levofloxacin and imipenem were 83.93％, 90.74％, 84.75％and 67.80％respectively, while which of the adeR gene negative group were 58.33％, 73.91％, 56.00％and 44.00％respectively, the differences between the two groups were statistically significant (P＜0.05).Conclusion The detection rate of efflux pump gene adeR in Acinetobacter baumannii is higher and highly correlated to the commonly used antibacterial drugs in clinic, which suggests that the efflux system is one of the important reasons for multi-drug resistance of Acinetobacter baumannii in local region.关键词
鲍曼不动杆菌/耐药/外排泵/adeR基因Key words
Acinetobacter baumannii/multidrug resistance/efflux pump/adeR gene分类
医药卫生引用本文复制引用
蔡燕,曾丽红,潘雪,梁奕,彭乙华,青鑫,何城,张婷,黄义山..鲍曼不动杆菌主动外排系统adeR基因分布及耐药性分析[J].检验医学与临床,2019,16(4):438-440,3.基金项目
四川省教育厅课题(10ZB069) （10ZB069）
