检验医学与临床2019，Vol.16Issue(4)：460-463,4.DOI:10.3969/j.issn.1672-9455.2019.04.008
不同压力二氧化碳气腹对腹腔镜胆囊切除术患者凝血及纤溶功能的影响
Effect of different pressures of carbon dioxide pneumoperitoneum on blood coagulation and fibrinolysis function in patients with laparoscopic cholecystectomy
摘要
Abstract
Objective To observe the effect of different pressures of carbon dioxide pneumoperitoneum on blood coagulation and fibrinolysis function in the patients with laparoscopic cholecystectomy.Methods Sixty patients undergoing elective laparoscopic cholecystectomy were selected and randomly divided into the two groups according to the pneumoperitoneum pressure:low pressure group (10mm Hg) and high pressure group (14mm Hg), 30cases in each group.Venous blood samples were taken before surgery, at postoperative 1, 24hfor determining the levels of prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (Fib), DDimer (DD), alanine amino transferase (ALT), aspartate amino transferase (AST).Results The levels of PT, AST and ALT at each time point had no statistical difference between the two groups (P＞0.05).Compared with before surgery, APTT at postoperative 24hin the two groups was significantly shortened (P＜0.05), while the levels of FIB and DD were increased significantly (P＜0.05), moreover the increasing range of FIB and DD in the high pressure group was significantly greater than that in the low pressure group (P＜0.05).Conclusion Low and high pneumoperitoneum pressure may lead to postoperative hypercoagulable status in laparoscopic cholecystectomy, but lower pneumoperitoneum pressure has less effect on blood coagulation and fibrinolysis function and is conducive to preventing the vein thrombosis.关键词
腹腔镜胆囊切除术/气腹压力/凝血酶原时间/活化部分凝血活酶时间/纤维蛋白原/D-二聚体Key words
laparoscopic cholecystectomy/pneumoperitoneum pressure/thromboplastin time/activated partial thromboplastin time/fibrinogen/DDimer分类
医药卫生引用本文复制引用
程燕,张宁,陈京,汪文君..不同压力二氧化碳气腹对腹腔镜胆囊切除术患者凝血及纤溶功能的影响[J].检验医学与临床,2019,16(4):460-463,4.基金项目
河北省邯郸市科学技术研究与发展计划(1823208018ZC) （1823208018ZC）
