临床神经外科杂志2019，Vol.16Issue(1)：80-83,4.DOI:10.3969/j.issn.1672-7770.2019.01.019
经鼻-蝶显微切除垂体腺瘤的疗效及对不同内分泌激素水平的监测意义
Surgical effect of pituitary adenoma by endonasal transsphenoidal approach and significance of monitoring different endocrine hormone levels
摘要
Abstract
Objectives To explore the surgical effect of pituitary adenoma by unilateral endonasal transsphenoidal approach. Methods The clinical data of 145 patients with pituitary adenoma microsurgery resection by unilateral endonasal transsphenoidal approach in the Sixth Affiliated Hospital of Guangzhou Medical University between January 2010 and June 2017 were analyzed retrospectively. Resection rang, clinical effect and the level of serum prolactin (PRL) and growth hormone (GH) before and after surgery were compared. Results All 145 cases were followed by 6 months, clinical symptoms, including headache、visual field defects、visual deterioration、neroendocrine disorders (amenorrhea lactation, sexual dysfunction, acral growth, abnormal hormone levels, centrality obesity, etc) were improved significantly. The level of serum PRL and GH were significantly lower than before operation on postoperative 1 d, 7 d, 14 d, but no obvious change in uncomplete tumor resection group. The level of serum PRL and GH on postoperative 1 d, 7 d, 14 d were obviously lower compared with two groups, the difference was statiscally significant (P ＜ 0. 005). Conclusion Pituitary Adenoma Resection by Unilateral Endonasal Transsphenoidal Approach has certain advantages of small trauma, little invasion, and low complicationsl et. besides can obviously improve clinical symptoms and the hormone levels of PRL or GH, therefore it is of high value in clinical application.关键词
单鼻孔蝶窦入路/显微手术/垂体腺瘤Key words
unilateral endonasal transsphenoidal/microsurgery/pituitary adenoma分类
医药卫生引用本文复制引用
邓光策,李国峰,曾敏敏,王岳华,关北漩,李凯舒..经鼻-蝶显微切除垂体腺瘤的疗效及对不同内分泌激素水平的监测意义[J].临床神经外科杂志,2019,16(1):80-83,4.基金项目
清远市科技计划项目 (2015B038) （2015B038）
