临床神经外科杂志2019，Vol.16Issue(1)：84-88,5.DOI:10.3969/j.issn.1672-7770.2019.01.020
CT灌注成像评估兔创伤性脑损伤后不同干预方式下脑血流动力学的变化
Preliminary study on assessment of cerebral hemodynamics changes (under different intervention methods) after traumatic brain injury in rabbits by computed tomography perfusion imaging
摘要
Abstract
Objective To explore the cerebral hemodynamics changes of traumatic brain injury in rabbits under different interventions by computed tomography perfusion (CTP) imaging. Methods Forty New Zealand white rabbits were randomly divided into control, compression, common decompression and controlled decompression group.The animal model was established by injecting water into a balloon in the epidural space of rabbit under intracranial pressure monitoring. The common decompression and controlled decompression groups, in addition to interventions, received two different procedures of decompression. Conventional CT scan and CTP imaging were performed after the animal model successfully constructed. The regional cerebral blood flow (rCBF) , the regional cerebral blood volume (rCBV) and mean transit time (MTT) of interest of each group were determined and compared statistically. The blood brain barrier (BBB) permeability was evaluated by Evans blue assay. Results Both the values of rCBF and rCBV in the basal ganglia region and temporal lobe were prominently lower in compression, common decompression and controlled decompression group than those in control group, while the values of MTT were significantly longer (All P ＜ 0. 01). There were also significant differents in the values of rCBF, rCBF and MTT in the groups (All P ＜0. 01). The content of Evans blue in the experimental group was higher than that in the control group (All P ＜0. 01) , and the difference was also statistically significant among the groups (All P ＜ 0. 01). Conclusions CTP imaging palys a key role in evaluating the changes of cerebral hemodynamics after traumatic brain injury. Controlled decompression can relieve the abnormal changes of cerebral hemodynamics after brain injury.关键词
创伤性脑损伤/CT灌注成像/脑血流动力学Key words
traumatic brain injury/CT perfusion imaging/cerebral hemodynamic分类
医药卫生引用本文复制引用
陈克非,代飞虎,李光旭,董吉荣,王玉海,郎巍巍..CT灌注成像评估兔创伤性脑损伤后不同干预方式下脑血流动力学的变化[J].临床神经外科杂志,2019,16(1):84-88,5.基金项目
无锡市卫计委科研项目 (MS201527) （MS201527）
