临床误诊误治2019，Vol.32Issue(3)：21-24,4.DOI:10.3969/j.issn.1002-3429.2019.03.006
脾氨肽联合维生素A、E治疗反复性呼吸道感染患儿的临床效果及其对免疫功能的影响
Efficacy of Spleen Aminopeptide Combined with Vitamin A and E in the Treatment of Children with Recurrent Respiratory Tract Infection and its Immune Function
摘要
Abstract
Objective To explore the clinical effect of spleen aminopeptide combined with vitamin A and E and their effect on the immune function of children with recurrent respiratory tract infection (RRTI). Methods A total of 130 children with RRTI admitted to our hospital from December 2016 to January 2018 were randomly divided into observation group (n=67) and control group (n=63). Both groups were given conventional treatment such as anti-infection, abatement of fever, cough relief and nutrition enhancement during acute infection. In the meantime, the control group was treated with vitamin A and E. On the basis of the control group, the observation group was supplemented with Spleen Aminopeptide Oral Solution. Both groups were treated for 2 months. The clinical efficacy was observed, and the changes of T lymphocyte subsets and immunoglobulin levels were detected. In addition, the occurrence of adverse reactions was recorded. Results The total clinical effective rates of the observation group and the control group were 91.04％ (61/67) and 73.02％ (46/63) respectively, and the difference was statistically significant (χ2=7.239, P=0.013). Compared with those before treatment, the levels of CD3+, CD4+, CD4+/CD8+, IgG, IgM and IgE in the observation group were increased while the levels of CD8+ were decreased significantly after treatment (P＜0.05). Compared with the control group, the levels of CD3+, CD4+, CD4+/CD8+, IgG, IgM and IgE in the observation group were increased significantly and the levels of CD8+ were decreased significantly after treatment (P＜0.01). There were no obvious adverse reactions during the treatment. Conclusion Spleen aminopeptide combined with vitamin A and E in the treatment of children with RRTI can effectively improve the clinical efficacy and the body's immunity, which is, therefore, conducive to the prognosis of children.关键词
呼吸道感染/维生素A/维生素E/脾氨肽/免疫因子Key words
Respiratory tract infections/Vitamin A/Vitamin E/Spleen amino peptide/Immunologic factors分类
医药卫生引用本文复制引用
王薇,李玉雪,胡民..脾氨肽联合维生素A、E治疗反复性呼吸道感染患儿的临床效果及其对免疫功能的影响[J].临床误诊误治,2019,32(3):21-24,4.基金项目
石家庄市科学技术研究与发展计划项目(161460623) （161460623）
