临床与实验病理学杂志2019，Vol.35Issue(1)：10-13,4.DOI:10.13315/j.cnki.cjcep.2019.01.003
前列腺癌组织中N-Myc、p53的表达及其临床意义
Expression and clinical significance of N-Myc and p53 in prostate cancer tissues
摘要
Abstract
Purpose To detect the expression of N-Myc and p53 in the tissues of prostate cancer (PCa) patients and to explore the relationship between them and their significance.Methods A total of 63 patients with PCa and 50 patients with benign prostatic hyperplasia (BPH) who underwent prostate surgery at the First Affiliated Hospital of Anhui Medical University were recruited in 2015-2016. The expression of N-Myc and p53 in pathological tissues were detected by immunohistochemistry of MaxVision method. Results The expression of N-Myc and p53 in PCa tissues was increased (P < 0.05). The expression of N-Myc and p53 in PCa tissues was correlated with bone metastases and TNM stage (P < 0.05), but not related to patient age, preoperative PSA level and other factors (P> 0.05). In addition, the expression of p53 was also correlated with Gleason score.Conclusion The high expression of N-Myc and p53 in PCa may involved in the malignant progression and metastasis of prostate cancer, and it is expected to become a new target for detecting PCa metastasis.关键词
前列腺肿瘤/前列腺增生/N-Myc/p53/免疫组织化学Key words
prostate neoplasm/benign prostatic hyperplasia/N-Myc/p53/immunohistochemistry分类
医药卫生引用本文复制引用
何桂芳,黄晓娟,郑露露,张力,徐凌凡,梁朝朝,蔡永萍,尹玉..前列腺癌组织中N-Myc、p53的表达及其临床意义[J].临床与实验病理学杂志,2019,35(1):10-13,4.基金项目
中国博士后科学基金第59批面上资助(2016M590561) （2016M590561）
中国博士后科学基金第10批特别资助(2017T100441) （2017T100441）
安徽省博士后研究人员科研活动经费资助(2015B051) （2015B051）
