临床与实验病理学杂志2019，Vol.35Issue(1)：23-27,5.DOI:10.13315/j.cnki.cjcep.2019.01.006
涎腺腺样囊性癌中MYB蛋白的表达及其意义
Expression of MYB protein in adenoid cystic carcinoma of the salivary gland
摘要
Abstract
Purpose To investigate the role of MYB in adenoid cystic carcinoma (ACC) of different origins and grades.Methods A total of 103 specimens of salivary gland tumors with complete pathologic data were collected from the Department of Pathology, Affiliated Hospital of Inner Mongolia Medical University. 64 cases of ACC of the salivary gland, which included 19 cases of grade I, 27 cases of grade Ⅱ, and 18 cases of grade Ⅲ were selected as experimental group. 7 cases of exrras-alivary ACC and 32 cases of non-ACC benign and malignant tumor of salivary gland were served as control group. The MYB protein expression was detected by MYB immunohistochemical En Vision two-step staining for both experimental and control group. Results The positive expression rates of MYB in 64 cases of salivary ACC and 7 cases of extrasalivary ACC were 54.69％ (35/64) and 57.14％ (4/7), respectively, with no statistically significant difference (P> 0.05). The positive expression rates of MYB in 64 cases of salivary ACC and 32 cases of non-ACC salivary benign and malignant tumors were 54.69％ (35/64) and 6.25％ (2/32), respectively, which showed statistically significant difference (P < 0.05). The positive expression rates of MYB were 68.42％ (13/19), 66.67％ (18/27) and 14.29％ (4/18) in 64 cases of salivary ACC Ⅰ, Ⅱ and Ⅲ, respectively, and the difference was significant (P <0.05). The difference between grade Ⅰ and Ⅱ was not statistically significant (P> 0.016 7), while compared with grade Ⅲ, there was a statistical increase of positive expression rate of MYB in both grade Ⅰ and Ⅱ (P < 0.016 7). Conclusion MYB is highly expressed in grade I and Ⅱ of the salivary ACC and low expressed in grade Ⅲ. It is speculated that there may be other fusion gene mutation in salivary ACC grade Ⅲ. MYB is lowly expressed in non-ACC benign and malignant tumors of salivary gland, suggesting that MYB protein expression has a certain diagnostic value for the diagnosis of salivary ACC.关键词
涎腺肿瘤/腺样囊性癌/免疫组织化学/MYBKey words
salivary gland neoplasm/adenoid cystic carcinoma/immunohistochemistry/MYB分类
医药卫生引用本文复制引用
王雨,唐俊杰,袁宏伟,贾永峰,施琳..涎腺腺样囊性癌中MYB蛋白的表达及其意义[J].临床与实验病理学杂志,2019,35(1):23-27,5.基金项目
内蒙古自然科学基金[2017MS(LH)0827] （LH）
内蒙古自治区卫生计生科研计划(201702053) （201702053）
