临床与实验病理学杂志2019，Vol.35Issue(2)：143-146,4.DOI:10.13315/j.cnki.cjcep.2019.02.004
β-catenin不同表达定位与胃癌临床病理特征的关系
Different expression localization of β-catenin and its correlation with clinical pathological parameters in gastric cancer
摘要
Abstract
Purpose To identify the significance of different expression localization of β-catenin and its correlation with clinical pathological parameters in gastric cancer (GC) . Methods The expression of β-catenin proteins in 120 gastric cancer and 50 normal gastric mucosa samples was detected by SP immunohistochemistry. Results The positive expression of β-catenin was localized to membrane with positive rate 100. 00％ in normal gastric mucosa. Lack of β-catenin membrane expression and ectopic expression in cytoplasm,nuclei,or cytoplasm/nuclei were found in GC tissue and the abnormal expression rate was as high as 81. 67％ (98/120) . The abnormal expression of β-catenin was significantly correlated with histological differentiation,lymphatic metastasis and TNM stage in GC (P < 0. 05) . The nuclear expression rate of β-catenin was 36. 67％ (44/120) ,and the positive nuclear expression was significantly correlated with TNM stage in GC (P < 0. 05) . The 5-year overall survival rate of β-catenin nuclear positive patients was significantly lower than that of nuclear negative ones (P < 0. 05) . Conclusion β-catenin plays a significant role in gastric cancer carcinogenesis,and its different expression localization is related to the progress of GC. β-catenin is expected to be a potential target for diagnosis and treatment of GC.关键词
胃肿瘤/β-catenin/表达定位/免疫组织化学Key words
gastric neoplasms/ β-catenin/ expression localization/ immunohistochemistry分类
医药卫生引用本文复制引用
程玉,刘小超,薛晶,郝美玲..β-catenin不同表达定位与胃癌临床病理特征的关系[J].临床与实验病理学杂志,2019,35(2):143-146,4.基金项目
河北省重点学科建设项目[冀教高(2013) 4号] （2013）
