临床与实验病理学杂志2019，Vol.35Issue(2)：151-154,4.DOI:10.13315/j.cnki.cjcep.2019.02.006
胃癌中β3GnT8的表达及临床意义
Expression of β3GnT8 in gastric cancer and its clinical significance
摘要
Abstract
Purpose To study the expression and the clinical significance of β3GnT8,MMP-2,PCNA in gastric cancer tissue. Methods The histological chips of paraffin specimens of gastric cancer were prepared,and immunohistochemical methods were used to detect the expression of β3GnT8,MMP-2 and PCNA in gastric cancer and adjacent tissue. Results The expression of β3GnT8 and MMP-2,PCNA in gastric cancer was higher than that in adjacent tissue (P = 0. 001) . The expression of β3GnT8 and MMP-2 was significantly positively correlated with the clinical stage (P = 0. 001) ,depth of invasion (P = 0. 011) and lymph node metastasis (P = 0. 003) of gastric cancer. The expression of β3GnT8 was significantly positively correlated with that of MMP-2 (r = 0. 703,P = 0. 001) and PCNA (r = 0. 231,P = 0. 024) . The overall survival time of the β3GnT8 positive expression group was significantly shorter than that of the negative expression group(χ2 = 3. 957,P = 0. 047) . Conclusion The expression of β3GnT8 is increased in gastric cancer. β3GnT8 can promote the invasion and metastasis of gastric cancer and is associated with poor prognosis in patients with gastric cancer.关键词
胃肿瘤/β3GnT8/MMP-2/PCNA/免疫组织化学Key words
gastric neoplasms/ β3GnT8/ MMP-2/ PCNA/ immunohistochemistry分类
医药卫生引用本文复制引用
刘振华,吴士良,黄山,干文娟,张永胜..胃癌中β3GnT8的表达及临床意义[J].临床与实验病理学杂志,2019,35(2):151-154,4.基金项目
国家自然科学基金(30670462) （30670462）
