临床与实验病理学杂志2019，Vol.35Issue(3)：263-267,5.DOI:10.13315/j.cnki.cjcep.2019.03.003
三阴型乳腺癌中CYP4A11和CYP4A22表达及其与M2型肿瘤相关巨噬细胞的关系
Expression of CYP4A11 and CYP4A22 in triple negative breast carcinoma and its relation to M2 tumor-associated macrophages
摘要
Abstract
Purpose To investigate the expression of CYP4 A11 and CYP4 A22 in triple-negative breast carcinoma (TNBC) and its relationship with clinicopathological features and M2 tumor-associated macrophages (TAMs). Methods 72 cases of TNBC with clinical and pathological data were collected. The expression of CYP4 A11 and CYP4 A22 in the carcinoma cells and the expression of CD68 and CD163 of the TAMs were detected by immunohistochemically and analyzed with image processing software. The relationship between the expressions of CYP4 A11 and CYP4 A22 with clinicopathologic features and its correlation of the M2 state of TAMs was studied. Results Both the immunohistochemically staining scores of CYP4 A11 and CYP4 A22 were higher in cancer tissues than that in breast tissues (P<0.001, P<0.001). The higher expression of CYP4 A11 was associated with tumor diameter increase (P<0.001), lymph node metastasis (P<0.001), higher clinical stage (P<0.001) and higher Ki-67 index (P=0.011). Both the positive rates of CD68 and CD163 in the high expression group of CYP4 A11 were higher than those in the low expression group of CYP4 A11 (P=0.021, P<0.001). The higher expression of CYP4 A22 was associated with lymph node metastasis (P<0.001), higher clinical stage (P=0.006), higher recurrence rate (P<0.001), and higher Ki-67 index (P=0.040).The positive rates of CD163 in the high expression group of CYP4 A22 was higher than that in the low expression group of CYP4 A22 (P<0.001). Conclusion Both the expression of CYP4 A11 and CYP4 A22 may be associated with M2 polarization state of TAMs, high proliferative activity and lymph node metastasis in the TNBC.关键词
乳腺肿瘤/CYP4A11/CYP4A22/免疫组织化学Key words
breast neoplasm/CYP4A11/CYP4A22/immunohistochemistry分类
医药卫生引用本文复制引用
何佳慧,邬万新,陈彩萍,郭志琴,王振,陆宁,温晓伟..三阴型乳腺癌中CYP4A11和CYP4A22表达及其与M2型肿瘤相关巨噬细胞的关系[J].临床与实验病理学杂志,2019,35(3):263-267,5.基金项目
嘉兴市科技计划(2017BY18009、2013AY21042-3) （2017BY18009、2013AY21042-3）
