临床与实验病理学杂志2019，Vol.35Issue(3)：278-281,4.DOI:10.13315/j.cnki.cjcep.2019.03.006
分泌性乳腺癌6例临床病理分析
Secretory breast carcinoma: a clinicopathological study of 6 cases
摘要
Abstract
Purpose To describe the clinicopathologic features, diagnosis and differential diagnosis, and prognosis of secretory breast carcinoma (SBC). Methods Clinicopathological and follow-up data of six SBC patients were collected. Histopathologic analysis was performed on hematoxylin and eosinstained (HE) section. Immunohistochemical staining was performed by En Vision two-step method and ETV6 gene detected by fluorescence in situ hybridization (FISH), then relevant literatures were reviewed. Results The ages of the patients ranged from 6 to 76 years with a mean age of 38.7 years, including one male and five female patients. The right breast was involved in 4 cases, and the left, in 2 cases. Five cases showed painless breast mass while one presented with a nipple discharge. The tumor size ranged from 1.0 to 3.1 cm with a mean size of 2.0 cm. Most of the tumors were circumscribed, solid gray white to light brown. Histologically, tumor showed solid nested microcystic, glandular or papillary pattern separating by hyaline fibrous tissue and growed in multiple nodular from. The cytoplasm contains abundant eosinophilic secretions or secretory vesicles. Immunhistochemistry, all cases were positive for CK7, S-100 and CEA, but negative for estrogen and progesterone receptors (ER and PR) and HER-2, and the proliferation index Ki-67 ranged from 10％ to 40％. Molecular testing confirmed the presence of the EVT6 gene translocation in one case. Lumpectomy was performed in 2 cases and modified radical mastectomy in 4 cases, two of them had lymph node metastasis (3/15, 1/16). Five cases were followed up for 6 months to 20 years, 1 case had lung metastasis. Conclusion SBC is a rare breast tumor with relatively indolent clinical and good prognosis. It can be diagnosed according to typical pathological morphology and immunohistochemical characteristics. The characteristic EVT6 gene translocation also has important differential diagnostic value.关键词
乳腺肿瘤/分泌性癌/免疫组织化学/分子特征/预后Key words
breast neoplasm/secretory carcinoma/immunohistochemistry/molecular characteristics/prognosis分类
医药卫生引用本文复制引用
陈慧萍,胡桂明,李新敏,任志敏,张瑶,古雅丽..分泌性乳腺癌6例临床病理分析[J].临床与实验病理学杂志,2019,35(3):278-281,4.基金项目
河南省高等学校重点科研项目(19B320020) （19B320020）
