临床与实验病理学杂志2019，Vol.35Issue(3)：282-285,4.DOI:10.13315/j.cnki.cjcep.2019.03.007
PTP1B蛋白高表达在卵巢癌临床预后评价中的意义
Significance of high expression of PTP1B in the valuation of progenosis of ovarian cancer
彭青群 1徐智燕 1甘跃敏 1赵瑞君2
作者信息
- 1. 江西省乐平市妇幼保健院妇产科,乐平 333300
- 2. 江西省南昌市第三医院乳腺疾病诊疗中心,南昌 330009
- 折叠
摘要
Abstract
Purpose To investigate the expressions of PTP1B in epithelial ovarian cancer tissues and to analysis its correlation with clinical pathological and survival significance.Methods The expression of PTP1B in ovarian cancer tissues was detected by Oncomine database and immunohistochemistry.The relationships between PTP1B expression and clinicopathological features, including prognosis significance, were analyzed. Results Oncomine database showed that the mRNA expression of PTP1B in ovarian cancer was significantly higher than that in normal tissues (P<0.001). Immunohistochemical staining showed that PTP1B expression was significantly correlation with FIGO stage (P<0.001), omentum majus metastasis (P=0.002). Kaplan-Meier analyses revealed that ovarian cancer patients with high PTP1B expression tumors had a significantly worse overall survival rate than those with low PTP1B expression tumors (P<0.001). Multivariate analysis showed that FIGO stage, PTP1B expression were independent survival predictors.Conclusion PTP1B expression may be involved in the tumor progression and poor prognosis of patients with ovarian cancer, and it might be used as one of the valuable markers for poor prognosis in patients with ovarian cancer.关键词
卵巢肿瘤/PTP1B/免疫组织化学/预后Key words
ovarian neoplasm/PTP1B/immunohistochemistry/prognosis分类
医药卫生引用本文复制引用
彭青群,徐智燕,甘跃敏,赵瑞君..PTP1B蛋白高表达在卵巢癌临床预后评价中的意义[J].临床与实验病理学杂志,2019,35(3):282-285,4.
