临床与实验病理学杂志2019，Vol.35Issue(3)：299-303,5.DOI:10.13315/j.cnki.cjcep.2019.03.011
肺孤立性纤维性肿瘤7例临床病理分析
Intrapulmonary solitary fibrous tumor: a clinicopathologic analysis of seven cases
摘要
Abstract
Purpose To investigate the clinicopathologic features and differential diagnosis of intrapulmonary solitary fibrous tumor (SFT). Methods Features of pathology and immunohistochemical stains of 7 cases of intrapulmonary SFT were described, with review of the literatures. Results There were 4 females and 3 males in the 7 cases, aged from 24 to 65. The tumors were located in the right lobe of lung. Clinically the patients were characterized by coughing and chest pain. The tumor size ranged from 1.2 to 9.0 cm. Microscopically, it was consistent with SFT in other sites;the lesion displayed a histologic pattern with alternate hypercellular and hypocellular areas;tumor cells were admixed with collagenous stroma and arranged in bundles or swirl or hemangiopericytoma-like pattern. The cells presented short spindle, light to moderate atypia and were characterized by low mitose activity (<4/10 HPF);there was necrosis in 2 cases and epithelioid cells in 1 case;there was slite-like structure lined by benign alveolar epithelium of in all 7 cases.Immunohistochemically, the tumor cells were positive for vimentin, STAT6, CD34, BCL-2 and CD99 in areas and negative for others. Conclusion Intrapulmonary SFT is fairly rare. Its diagnosis relies mainly on imaging and histopathology and immunohistochemistry helps to distinguish it from other tumors such as pulmonary adenofibroma, malignant mesothelioma, synovial sarcoma, sarcomatoid carcinoma, the primary pulmonary meningioma. Patients have good prognosis, and radical surgery is a priority. We should pay more attention to long-term follow-up for the patients.关键词
肺肿瘤/孤立性纤维性肿瘤/免疫组织化学/病理特点/预后Key words
lung neoplasm/solitary fibrous tumor/immunohistochemistry/pathologic feature/prognosis分类
医药卫生引用本文复制引用
梁华,宫惠琳,杨喆,张冠军..肺孤立性纤维性肿瘤7例临床病理分析[J].临床与实验病理学杂志,2019,35(3):299-303,5.基金项目
陕西省国际合作项目(S2016YFKW0042) （S2016YFKW0042）
