西南医科大学学报2019，Vol.42Issue(1)：20-26,7.DOI:10.3969/j.issn.2096-3351.2019.01.004
增补维生素A预防支气管肺发育不良的Meta分析
Vitamin A supplementation for the prevention against bronchopulmonary dysplasia: a Meta analysis
摘要
Abstract
Objective:To systematically assess the efficacy and safety of early supplementation of vitamin A in preterm infants in the prevention agaiust bronchopulmonary dysplasia.Methods:Databases including PubMed, Embase, Cochrane Library, CBM, WanFang Data, CNKI and VIP were searched to collect randomized controlled trials (RCTs) about early supplementation of vitamin A in preterm infants in the prevention of bronchopulmonary dysplasia from inception to July 1, 2018. Then Meta analysis was conducted by RevMan 5.3 software.Results:A total of 9 RCTs, involving 1 409 neonates were included. The results showed that, when supplementation of vitamin A by intramuscular injection, the incidence of oxygen inhalation at 36 weeks' postmenstrual age was lower (RR = 0.85, 95％CI:0.73 to 0.98, P = 0.03), and there were no statistically significant differences between the two groups on the incidence of mortality at 36 weeks' postmenstrual age, oxygen inhalation at 28 days, mortality at 28 days, sepsis. When supplementation of vitamin A orally, no significant differences between the two groups were detected on the incidence of oxygen inhalation at 36 weeks' postmenstrual age, mortality at 36 weeks' postmenstrual age, oxygen inhalation at 28 days, mortality at 28 days. Given by intravenous injection decreased the rate of oxygen inhalation at 28 days without statistically significant difference. Vitamin A supplementation didn't increase the occurrence of adverse reactions.Conclusions:Supplementation of vitamin A by intramuscular injection decreases the incidence of oxygen inhalation at 36 weeks' postmenstrual age, but there is no significant difference on the incidence of oxygen inhalation at 28 days. More high quality studies are needed to verify the efectiveness of supplementation of vitamin A orally and intravenously for prevention agaiust bronchopulmonary dysplasia. It is safe when vitamin A is supplementated by routine does.关键词
维生素A/支气管肺发育不良/出生时低体重/早产儿Key words
Vitamin A/Bronchopulmonary dysplasia/Low Birth Weight/Premature baby分类
医药卫生引用本文复制引用
江开平,董文斌..增补维生素A预防支气管肺发育不良的Meta分析[J].西南医科大学学报,2019,42(1):20-26,7.基金项目
国家自然科学基金面上项目(81571480) （81571480）
