西南医科大学学报2019，Vol.42Issue(1)：27-30,4.DOI:10.3969/j.issn.2096-3351.2019.01.005
血浆S100B、Tau、NSE在晚期早产儿胆红素神经损害中的预测价值
Predictive value of plasma S100B and Tau protein and NSE level in bilirubin induced-nerve damage in late preterm infants
摘要
Abstract
Objective:To investigate the predictive value of plasma S100 B, Tau protein and NSE level in bilirubin induced-nerve damage in late preterm infants.Methods:We enrolled 190 late preterm infants admitted to NICU from May 2016 to December 2017. They were divided into an observation group with hyperbilirubinemia and a control group without hyperbilirubinemia. According to total serum bilirubin (TSB) level, the observation group was divided into three subgroups: mild, moderate and severe elevation. On the first day after birth, changes of venous plasma S100 B, Tau protein and NSE levels were measured by ELISA, and TSB level were measured by DIAZO method. Neural development based on a neonatal behavioral neurological assessment (NBNA) score was detected 7 days after birth. Brainstem auditory evoked potential (BAEP) was measured, and brain magnetic resonance imaging (MRI) was performed 10 days after birth in the observation group.Results:Levels of NSE, S100 B and Tau protein in the observation were higher than those in the control group, especially in the moderate and severe hyperbilirubinemic subgroups (P ＜ 0.05), and the level of plasma S100 B, Tau and protein NSE in the observation group was higher than that in the control (P ＜ 0.05), and those protein levels of the gestational age (GA) 34 W group were higher than those in the GA35 W and GA36 W subgroups (P ＜ 0.05). The NBNA score of GA34 W was significantly lower than that of the other two GA subgroups (P ＜ 0.05), and the hyperintensity on T1 WI by MRI in the observation group (moderate and severe hyperbilirubinemic subgroups), especially in the severe hyperbilirubinemic group was significantly higher than that in the mild subgroup and the control (P ＜ 0.05).Conclusion:Early detection of plasma S100 B, Tau protein and NSE level combined with NBNA, BAEP and MRI was helpful in the identification of bilirubin neuronal damage in late preterm infants, and was of important clinical significance in the prevention of bilirubin encephalopathy.关键词
S100B/Tau/NSE/晚期早产儿/胆红素神经损害Key words
S100B/Tau/NSE/Late premature infants/Bilirubin relatived nerve damage分类
医药卫生引用本文复制引用
孙凤杰,李娟,邓长柏,佟德民..血浆S100B、Tau、NSE在晚期早产儿胆红素神经损害中的预测价值[J].西南医科大学学报,2019,42(1):27-30,4.基金项目
广东省科技计划项目(20140212) （20140212）
广州市医药卫生科技项目(20151A011094,20161A011091) （20151A011094,20161A011091）
