山东医药2019，Vol.59Issue(4)：1-5,5.DOI:10.3969/j.issn.1002-266X.2019.04.001
骨钙素在不同糖耐量人群的水平变化及对糖脂和骨代谢的影响
Osteocalcin levels in people with different glucose tolerance and its effects on glucose, lipid, and bone metabolism
摘要
Abstract
Objective To explore the serum level of osteocalcin (OC) in people with different glucose tolerance and to investigate the effects of OC on glucose, lipid, and bone metabolism. Methods Totally 373 patients were selected from the department of endocrinology, according to oral glucose tolerance test (OGTT), the subjects were divided into the following three groups: normal glucose tolerance group (NGT group, n = 99), impaired glucose regulation group (IGR group, n = 43) and type 2 diabetes group (T2 DM group, n = 231). The fasting venous blood was collected to detect the blood biochemical indexes, bone mineral density (BMD), including BMD1, BMD2, BMD3, BMD4, BMD1-4, and DM2-4 and fatcontent, and then we compared the level of serum osteocalcin and its correlation with the glucose, lipid, and bone metabolism in these three groups. Results The T2 DM group had a significantly lower number of OC than NGT group and IGR group [15. 09 (11. 60-19. 30) vs. 19. 32 (14. 90-24. 45) vs 21. 12 (16. 15-25. 25) ng/mL, P ＜ 0. 05]. In the NGT group, OC was positively correlated with WHR (r = 0. 561, P = 0. 037), and negatively correlated with FPG, fat-content, BMD1, BMD2, BMD3, BMD4, BMD1-4, BMD2-4, and HOMA-IR (r =-0. 339, -0. 237, -0. 409, -0. 383, -0. 393, -0. 422, -0. 418, -0. 421 and-0. 543, P = 0. 001, 0. 024, 0. 001, 0. 003, 0. 002, 0. 001, 0. 001, 0. 001, and 0. 011). According to multiple regression analysis, BMD2-4 was an independent influencing factor for OC in the NGT group. In the IGR group, OC was positively correlated with age (r = 0. 323, P = 0. 048), and negatively correlated with HOMA-β (r =-0. 487, P = 0. 025). In the T2 DM group, OC was positively correlated with HOMA-β (r =0. 135, P = 0. 049), and negatively correlated with weight, UA, FPG, Ca, fat-content, BMD1, BMD2, BMD3, BMD4, BMD1-4 and BMD2-4 (r =-0. 210, -0. 156, -0. 187, -0. 151, -0. 135, -0. 329, -0. 327, -0. 304, -0. 323, -0. 344 and-0. 323, P = 0. 002, 0. 022, 0. 007, 0. 027, 0. 046, 0. 001, 0. 001, 0. 001, 0. 001, 0. 001, and 0. 001).According to multiple regression analysis, BMD2-4, fat-content, FPG, and Ca were independent influencing factors for OC. Conclusions Serum OC increases in IGR patients and decreases in T2 DM patients. Serum OC may influence glucose metabolism by regulating insulin sensitivity and the function of islet β-cell and inhibiting the accumulation of adipose tissues. OC may also play a role in the development of diabetic osteoporosis and served as an important marker for the reduction of BMD.关键词
2型糖尿病/骨钙素/糖代谢/脂代谢/骨密度Key words
type 2 diabetes mellitus/osteocalcin/glucose metabolism/lipid metabolism/bone mineral density分类
医药卫生引用本文复制引用
王红,梁丽芳,关雅心,左帆,蒋世钊,吴斌..骨钙素在不同糖耐量人群的水平变化及对糖脂和骨代谢的影响[J].山东医药,2019,59(4):1-5,5.基金项目
国家自然科学基金资助项目(81660141) （81660141）
云南省科技计划项目(2015FB023) （2015FB023）
