山东医药2019，Vol.59Issue(4)：10-13,4.DOI:10.3969/j.issn.1002-266X.2019.04.003
血浆氧化三甲胺检测对急性心肌梗死患者心室重构及预后的评估价值
Evaluation value of plasma trimethylamine oxide determination for ventricular remodeling and prognosis in patients with acute myocardial infarction
摘要
Abstract
Objective To investigate the evaluation value of plasma trimethylamine oxide (TMAO) determination for ventricular remodeling and prognosis in patients with acute myocardial infarction (AMI). Methods Totally 103 AMI patients were selected as the case group and 60 healthy persons as the control group. The plasma TMAO was measured by high performance liquid chromatography tandem mass spectrometry, ventricular remodeling parameter was examined by echocardiography, and the correlation analysis between ventricular remodeling parameter and plasma TMAO was performed.Adverse cardiovascular event within 6 months after percutaneous coronary intervention was recorded. The predictive value of TAMO for prognosis was assessed by area under curve (AUC) of receiver operating characteristic curve (ROC). Results Plasma TMAO level in the case group was higher than that in the control group (P ＜ 0. 001). Left atrial diameter (LAD), left ventricular posterior wall thickness (LVPWT), left ventricular posterior wall end-diastolic thickness (PWD), left ventricular posterior wall end-systolic thickness (PWS), left ventricular mass index (LVMI) were higher in the case group than in the control group (all P ＜ 0. 05), and left ventricular ejection fraction (LVEF) was lower than that in the control group (P ＜ 0. 05). The plasma TMAO level was positively correlated with LAD, LVPWT, PWD, PWS, and LVMI (r =0. 532, 0. 463, 0. 491, 0. 486, and 0. 569, all P ＜ 0. 05), and negatively correlated with LVEF (r =-0. 519, P ＜0. 05). Seventeen (16. 50％) cases of adverse cardiovascular events occurred at 6 months after PCI. The AUC of TMAO in evaluating the prognosis of patients with AMI at 6 months after PCI was 0. 877, 95％ CI was 0. 806-0. 947. At this time, the optimal truncation value of TMAO was 5. 08 μmol/L. The sensitivity and specificity were 0. 76 and 0. 89, respectively, and the accuracy was 0. 85. Conclusions The plasma TMAO level in AMI patients is elevated. Early detection of TMAO contributes to the assessment of ventricular remodeling and the prediction of prognosis.关键词
急性心肌梗死/氧化三甲胺/心室重构/预后Key words
acute myocardial infarction/trimethylamine oxide/ventricular remodeling/prognosis分类
医药卫生引用本文复制引用
袁晓宇,潘闵,杨鹏,陈楚,施伟慧,袁菊萍,黄中伟..血浆氧化三甲胺检测对急性心肌梗死患者心室重构及预后的评估价值[J].山东医药,2019,59(4):10-13,4.基金项目
江苏省科技计划项目(BK20170369) （BK20170369）
苏州市科技计划项目(SYS201616) （SYS201616）
