山西中医学院学报2018，Vol.19Issue(6)：13-16,4.
回医烙灸对大鼠腰椎间盘退变模型软骨基质的影响
The effect of moxibustion in Huiyi on cartilage matrix of lumbar intervertebral disc degeneration in rats
摘要
Abstract
Objective:To observe the effect of moxibustion in Huiyi on cartilage matrix of lumbar intervertebral disc degeneration in rats and cartilage matrix factor. Methods:A total of 40 adult SD rats were randomly divided into normal group, sham operation group, animal model group and moxibustion group. Each group was 10 rats. The experimental lumbar intervertebral disc degeneration was constructed by needling. The animals of moxibustion group were treated with moxibustion 8 weeks, then all the rats were executed and draw material. The changes of proteoglycan of lumbar intervertebral disc were observed by spectrophotometric method. The type II collagen fiber、MMP-3、TIMP-1 were detected by immunohistochemical. Results:The expression of proteoglycan and type II collagen fiber in normal group、sham operation group and moxibustion group were higher than those in model group (P＜0.05). The expression of MMP-3 in normal group、sham operation group and moxibustion group were lower than one in model group (P＜0.05). The expression of TIMP-1 in normal group、sham operation group and moxibustion group were higher than that in model group (P＜0.05). Conclusion:Moxibustion in Huiyi can control the expression of cartilage matrix in the experimental lumbar intervertebral disc degeneration model, and can regulate factor of cartilage matrix.It maybe delays and inhibits the degeneration of chondrocyte.关键词
腰椎间盘退变/回医烙灸疗法/软骨细胞基质Key words
Lumbar intervertebral disc degeneration/Moxibustion in Huiyi/Cartilage matrix分类
医药卫生引用本文复制引用
尤娜,许建峰,白帅,林瑞珠,马玉宝,牛子瞻,张彦明,王英絮..回医烙灸对大鼠腰椎间盘退变模型软骨基质的影响[J].山西中医学院学报,2018,19(6):13-16,4.基金项目
国家自然科学地区基金 (81760905) （81760905）
国家自然科学地区基金 (81360567) （81360567）
宁夏医科大学优势学科群建设科研项目 (XY201622) （XY201622）
第三批宁夏老中医药专家学术经验继承项目 (201659) （201659）
