上海针灸杂志2019，Vol.38Issue(2)：188-192,5.DOI:10.13460/j.issn.1005-0957.2019.02.0188
针灸联合知葛通脉颗粒对糖尿病周围神经病变患者中医证候积分、Hcy水平及神经传导功能的影响
Effect of Acupuncture-moxibustion plus Zhi Ge Tong Mai Granules on TCM Syndrome Score, Hcy and Nerve Conduction in Patients with Diabetic Peripheral Neuropathy
摘要
Abstract
Objective To observe the effect of acupuncture-moxibustion plus Zhi Ge Tong Mai granules on the traditional Chinese medicine (TCM) syndrome score, level of homocysteine (Hcy) and nerve conduction in patients with diabetic peripheral neuropathy (DPN). Method Ninety DPN patients were enrolled and randomized into a control group and an observation group. The control group only received Zhi Ge Tong Mai granules, and the observation group was intervened by acupuncture-moxibustion plus Zhi Ge Tong Mai granules. The clinical efficacy, TCM syndrome score, and levels of Hcy, nerve growth factor (NGF), insulin-like growth factor 1 (IGF-1) and vascular endothelial growth factor (VEGF), and nerve conduction function were observed for the two groups. Result The observation group had a higher total effective rate than the control group (P<0.05); the TCM syndrome score in the observation group was lower than that in the control group after treatment (P<0.05); the levels of Hcy and VEGF in the observation group were lower than those in the control group, and the levels of NGF and IGF-1 in the observation group were higher than those in the control group (P<0.05); after treatment, the motor and sensory conduction velocities of both left and right tibial nerves in the observation group were higher than those in the control group (P<0.05). Conclusion Acupuncture-moxibustion plus Zhi Ge Tong Mai granules can boost the clinical efficacy, and improve the TCM syndrome score, and the levels of factors such as Hcy and VEGF in patients with DPN.It can produce better efficacy than Zhi Ge Tong Mai granules alone.关键词
针灸疗法/针药并用/知葛通脉颗粒/糖尿病神经病变/中医证候积分/神经传导/同型半胱氨酸/神经生长因子/胰岛素样生长因子-1/血管内皮生长因子/糖尿病并发症分类
医药卫生引用本文复制引用
丁亚琴,李琦,吴坚,徐艺,竺春玲..针灸联合知葛通脉颗粒对糖尿病周围神经病变患者中医证候积分、Hcy水平及神经传导功能的影响[J].上海针灸杂志,2019,38(2):188-192,5.基金项目
上海市虹口区卫生和计划生育委员会医学科学计划项目(虹卫1704-06) （虹卫1704-06）
