水生生物学报2019，Vol.43Issue(2)：340-347,8.DOI:10.7541/2019.042
镉暴露诱导黄颡鱼鳃的组织学损伤、氧化应激和免疫反应
CADMIUM EXPOSURE INDUCES HISTOLOGICAL DAMAGE, OXIDATIVE STRESS AND IMMUNE RESPONSE IN YELLOW CATFISH
摘要
Abstract
To investigate the effect of different Cd (0 (control), 50, and 200 μg/L Cd2+) on Yellow catfish (Pelteobagrus fulvidraco), fish were exposed for 8 weeks before analyzing the histological structure, antioxidant status and immune-related gene expression in gills. The results showed that Cd2+ exposure induced significant Cd accumulation and histological changes in gill, such as aneurism, hyperplasia, curling of lamella and cell desquamation. Meanwhile, Cd2+ increased the activity of glutathione-S-transferase (GST), glutathione peroxidase (GPx) and anti-hydroxyl radical (AHR) as well as the content of hydrogen peroxide (H2O2), and it decreased catalase (CAT) activity and glutathione (GSH) content. However, Cd2+ had no significant effect on superoxide dismutase (SOD) activity. In addition, Cd exposure up-regulated tumor necrosis factor-a (tnf-a), major histocompatibility complex (mhc), interleukin-10 (il-10), transforming growth factor-β (tgf-β) and complement factor C3 (c3) expressions, but down-regulated interleukin-1β (il-1β), interleukin-8 (il-8) and lysozyme (lys) transcription levels. These results showed that Cd exposure resulted in the accumulation of Cd, and induced histological damage, oxidative stress and immune response of gill in yellow catfish.关键词
镉暴露/鳃/黄颡鱼/氧化应激/免疫反应Key words
Cd exposure/Gill/Yellow catfish/Oxidative stress/Immune response分类
生物科学引用本文复制引用
龚仕玲,谢冬梅,李英文,陈启亮..镉暴露诱导黄颡鱼鳃的组织学损伤、氧化应激和免疫反应[J].水生生物学报,2019,43(2):340-347,8.基金项目
重庆市基础与前沿研究计划项目(cstc2015jcyjA80012) （cstc2015jcyjA80012）
重庆师范大学校级基金项目(15XLB012和YKC17009)资助 （15XLB012和YKC17009）
