实用医学杂志2019，Vol.35Issue(3)：445-448,4.DOI:10.3969/j.issn.1006-5725.2019.03.025
等效镇痛剂量舒芬太尼、芬太尼、地佐辛对意识指数的影响和不良反应的比较
Comparison of effects of equivalent analgesic dose of sufentanil, fentanyl and dezocine on consciousness index and their adverse reactions
孙茗 1刘骥 1韩晓林 1淡雄玉 1谢丽莎 1方伟武1
作者信息
- 1. 中国人民解放军第306医院麻醉手术科,北京 100101
- 折叠
摘要
Abstract
Objective To compare the effects of the equivalent analgesic doses of sufentanil, fentanyl and dizosin on index of consciousness (IoC) and their adverse reactions. Methods Eighty patients undergoing painless gastroenteroscopy, aged 18～60 years, ASA grade Ⅰ to Ⅱ, were selected. The patients were randomly divided into control group (group C) , sufentanil group (group S) , fentanyl group (group F) , and dizosin group (group D) , with 20 cases in each group. Sufentanil 0.1～0.2 μg/kg, fentanyl 1～2μg/kg and dizocine 0.1～0.2 mg/kg were intravenously injected in group S, F and D respectively. Group C was given saline of equal volume, and then propofol 2～2.5 mg/kg was intravenously injected until consciousness disappeared.Intravenous infusion of propofol50～100 g/ (kg · min) maintained anesthesia. Heart rate, blood pressure, IoC and perioperative adverse events were recorded. Results There was no significant difference in operative time and recovery time among the 4 groups (P> 0.05). Compared with those in group C, the values of IoC at T2, TS, T4 and T5 in group S and F increased significantly (P < 0.05) , and the correlation coefficient between OAA/S and IoC was 0.872 (P < 0.05). Compared with that in group C, the incidence of nausea and vomiting was higher in group D, and the incidence of injection pain was significantly lower in group S, F and D (P < 0.05). Conclusion Compared with propofol alone, opioids used in painless gastrointestinal endoscopy anesthesia lead to loss of consciousness and increase of IoC value at recovery time, but have no significant effect on recovery time.关键词
意识指数/不良反应/镇静/阿片类Key words
index of consciousness/adverse effects/analgesics/opioid引用本文复制引用
孙茗,刘骥,韩晓林,淡雄玉,谢丽莎,方伟武..等效镇痛剂量舒芬太尼、芬太尼、地佐辛对意识指数的影响和不良反应的比较[J].实用医学杂志,2019,35(3):445-448,4.
