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顶空固相微萃取气质联用法分析保心宁片中挥发性成分

郑月 徐建 许艳茹 石菊 赵俞 李芳 任晓楠 张显涛 唐纪琳

特产研究2019,Vol.41Issue(1):88-91,4.
特产研究2019,Vol.41Issue(1):88-91,4.DOI:10.16720/j.cnki.tcyj.2019.01.019

顶空固相微萃取气质联用法分析保心宁片中挥发性成分

Analysis of Volatile Constituents of Baoxinning Tablets by HS-SPME-GC-MS

郑月 1徐建 2许艳茹 2石菊 2赵俞 2李芳 3任晓楠 3张显涛 4唐纪琳1

作者信息

  • 1. 中国科学院长春应用化学研究所,长春 130022
  • 2. 吉林修正药业新药开发有限公司吉林省中药标准化关键工程技术重点实验室,长春 130012
  • 3. 修正药业集团股份有限公司,吉林 通化 134000
  • 4. 长春高新制药有限公司,长春 130012
  • 折叠

摘要

Abstract

The composition volatile constituents in Baoxinning tablets were investigated and a rapid method for the analysis of volatile constituents in Baoxinning tablets was established. The volatile constituents of Baoxinning tablets were extracted by headspace solid-phase micro-extraction method. The chemical composition of volatile constituents of Baoxinning tablets were identified by gas chromatographymass spectrometry. The relative content of constituents was determined by area normalization method. Thirty-six compounds were identified. The main volatile constituents of Baoxinning tablets were ketones, aldehydes and phenols.This study revealed the pharmacodynamic basis of Baoxining tablets from the perspective of volatile constituents. It provides scientific basis for its clinical application.

关键词

保心宁片/挥发性成分/顶空固相微萃取和气相色谱-质谱联用/化学成分

Key words

Baoxinning tablet/volatile constituents/HS-SPME-GC-MS/chemical constituents

分类

医药卫生

引用本文复制引用

郑月,徐建,许艳茹,石菊,赵俞,李芳,任晓楠,张显涛,唐纪琳..顶空固相微萃取气质联用法分析保心宁片中挥发性成分[J].特产研究,2019,41(1):88-91,4.

基金项目

吉林省科技发展计划(20160307011YY) (20160307011YY)

特产研究

OACSTPCD

1001-4721

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