中国组织工程研究2019，Vol.23Issue(9)：1448-1454,7.DOI:10.3969/j.issn.2095-4344.1619
诱导多能干细胞在心血管疾病中的应用:效率及安全性
Application of induced pluripotent stem cells in cardiovascular diseases: efficiency and safety
摘要
Abstract
BACKGROUND: Induced pluripotent stem cells are a type of reprogrammed cells with similar characteristics to embryonic stem cells, which are capable of differentiating into phenotypes associated with patient specific diseases. Moreover, their clinical application avoids ethical issues. OBJECTIVE: To review the research progress of induced pluripotent stem cells in myocardial regeneration and repair, cardiovascular disease models, drug development and screening, and drug toxicity testing. METHODS: PubMed (2006-2018) and CNKI (2013-2018) databases were retrieved for relevant articles using the keywords of "induction of pluripotent stem cells; myocardial infarction; arrhythmia; cardiovascular disease; heart failure; heart transplantation; disease model; drug toxicity" in English and Chinese, respectively. The data were reviewed one by one, and the citations involved in the literatures were also reviewed. RESULTS AND CONCLUSION: Induced pluripotent stem cells have great potential value in myocardial regeneration and repair, establishment of cardiovascular disease models, new drug development and screening, and drug toxicity detection. The application prospect of the cells is broad, but most of the research is still in the experimental stage. In addition, safety problems, such as low induction efficiency and tumorigenicity, will limit the clinical application of induced pluripotent stem cells.关键词
诱导多能干细胞/心血管疾病/心肌梗死/心律失常/心力衰竭/药物毒性分类
医药卫生引用本文复制引用
曾建银,韩燊,李亚雄,刘斌,张雅永,蒋立虹..诱导多能干细胞在心血管疾病中的应用:效率及安全性[J].中国组织工程研究,2019,23(9):1448-1454,7.基金项目
国家临床重点专科建设项目,云南省心血管外科治疗技术创新团队(2015HC015),项目负责人:李亚雄 （2015HC015）
云南省卫生科技计划项目,诱导心血管疾病患者iPSC向心肌细胞分化及其功能的研究(2017NS328),项目负责人:张雅永 （2017NS328）
云南省科技创新人才计划,昆明市延安医院心脏大血管外科关键诊疗技术研究省创新团队(2018HC027),项目负责人:李亚雄 （2018HC027）
