中国组织工程研究2019，Vol.23Issue(9)：1468-1476,9.DOI:10.3969/j.issn.2095-4344.1595
嗅鞘细胞治疗晚期脊髓损伤短期与长期疗效的Meta分析
Short-and long-term effects of olfactory ensheathing cells in the treatment of chronic spinal cord injury: a meta-analysis
摘要
Abstract
BACKGROUND: A number of clinical trials addressing olfactory ensheathing cells for the treatment of chronic spinal cord injury have been conducted in the world, but the efficacy and safety are still controversial. OBJECTIVE: To evaluate the safety and efficacy of olfactory ensheathing cell transplantation for chronic spinal cord injury, and to further compare its short-and long-term efficacy. METHODS: PubMed, Cochrane Library, EMBASE, CNKI and WanFang databases were searched at July 23, 2018 for retrieval of clinical trials addressing olfactory ensheathing cells in the treatment of chronic spinal cord injury. Types and cases of adverse events during the safety trial should be recorded in detail. In the enrolled studies, American Spinal Injury Association scale was used to assess the motor, light touch, and pinprick scores of spinal cord injury patients before and after cell transplantation. The follow-up time was recorded. Systematic evaluation of efficacy data was performed using Review Manager 5.3. RESULTS AND CONCLUSION: Both short-and long-term follow-up data showed that the neurological function of patients was significantly improved after olfactory ensheathing cell transplantation (P < 0.05), and the results were homogeneous (I2 < 50％ and P> 0.1). However, the long-term efficacy was not as good as the short-term efficacy, which may be related to chronic rejection and olfactory ensheathing cell survival. The overall adverse event rate was 8.99％, and no complications associated with olfactory ensheathing cells occurred. These findings show that olfactory ensheathing cell transplantation is effective and safe in the treatment of chronic spinal cord injury, but it is still necessary to explore more minimally invasive approaches to reduce surgical complications. In addition, a large number of high-quality experiments and clinical trials are warranted to confirm factors affecting the long-term efficacy of olfactory ensheathing cell transplantation.关键词
嗅鞘细胞/脊髓损伤/晚期脊髓损伤/细胞移植/人类/神经修复/ASIA评分/短期疗效/长期疗效/安全性/Meta分析分类
医药卫生引用本文复制引用
陈慧靖,陈雲,邓煜二,甘燕玲,詹文刚,谭齐家,谢才军,李聪,张志强..嗅鞘细胞治疗晚期脊髓损伤短期与长期疗效的Meta分析[J].中国组织工程研究,2019,23(9):1468-1476,9.基金项目
广东省科技计划项目(2014A020212411),项目负责人:张志强 （2014A020212411）
