中国组织工程研究2019，Vol.23Issue(10)：1599-1604,6.DOI:10.3969/j.issn.2095-4344.1575
经导管主动脉瓣流固耦合分析
Fluid structure interaction analysis of transcatheter aortic valve implantation
摘要
Abstract
BACKGROUND: Cardiac valve replacement provides an effective therapeutic means for valvular heart disease. Compared with thoracotomy surgery, interventional treatment, typified by transcatheter aortic valve implantation, has the advantages of minor trauma and rapid recovery. At present, the transcatheter aortic valve replacement is rarely applied in clinical practice. Existing studies mainly focus on the changes of physiological conditions after surgery, while little is reported on the transcatheter aortic valve models. OBJECTIVE: To explore the deformation and stress distribution features of the transcatheter aortic valve, and to verify its working performance. METHODS: The finite element geometric model and mathematical model of the aortic valve, including the aortic valve, blood vessel wall, blood and stent, were established. The fluid structure interaction analysis was carried out by the immersion boundary method, and the effective orifice area index was calculated to verify the performance of the model. RESULTS AND CONCLUSION: During the course of blood shock, the valve leaflets were curl, and the maximum deformation occurred at 1/4 and 3/4 of the valve leaflet free edge. The largest equivalent stress of the aortic valve model was on the stent, but it is almost unformed. The stress concentration of the valve leaflets was located at the curved site of the free edge and the suture points of the leaflets and stents, where a damage easily occurred. The dynamic flow experiments show that the process of the simulation model deformation and effective orifice area index are close to the experimental results. Therefore, the simulation model is reasonable and effective.关键词
经导管主动脉瓣置换/心脏瓣膜病/流固耦合/浸没边界法/支架/变形分析/应力分析/有效开口面积指数/国家自然科学基金分类
医药卫生引用本文复制引用
朱宏伟,袁泉,刘杏铭,丛华..经导管主动脉瓣流固耦合分析[J].中国组织工程研究,2019,23(10):1599-1604,6.基金项目
国家自然科学基金(31170906),项目负责人:袁泉 （31170906）
