中国组织工程研究2019，Vol.23Issue(10)：1626-1632,7.DOI:10.3969/j.issn.2095-4344.1598
功能化Fe3O4磁性纳米微粒在生物医学领域的应用
Applications of functional Fe3O4 magnetic nanoparticles in biomedical field
马捷 1王倩1
作者信息
- 1. 解放军空军军医大学西京医院骨科,陕西省西安市 710032
- 折叠
摘要
Abstract
BACKGROUND: Fe3O4 magnetic nanoparticles gradually become a hot research point in related research fields due to their unique superparamagnetic property, biocompatibility, specific targeting and low cytotoxicity. OBJECTIVE: To review the development of Fe3O4 magnetic nanoparticles in recent years as well as their applications in the biomedical field. METHODS: The first author retrieved the PubMed and CNKI databases for relevant articles published from January 2001 to October 2018 using the keywords of ―magnetic Fe3O4 nanoparticles‖, ―surface modification‖, ―biomedicine‖ in English and Chinese, respectively. RESULTS AND CONCLUSION: Fe3O4 magnetic nanoparticles are prone to oxidation and aggregation, and the lack of coupling groups on the surface limits the functionalization of the nanoparticles. Therefore, surface modification and processing of Fe3O4 magnetic nanoparticles by physical and chemical methods are warranted to achieve their further applications. Polymer molecules, organic small molecules and inorganic materials can be used for surface modification of Fe3O4 magnetic nanoparticles. At present, Fe3O4 magnetic nanoparticles have been applied in some new biomedical fields, such as magnetic resonance imaging, targeted drugs and gene carriers, immunoassays, biological separation and solidification enzymes.关键词
磁性纳米微粒/Fe3O4/表面改性/靶向治疗/生物医药/生物材料分类
医药卫生引用本文复制引用
马捷,王倩..功能化Fe3O4磁性纳米微粒在生物医学领域的应用[J].中国组织工程研究,2019,23(10):1626-1632,7.
