中国组织工程研究2019，Vol.23Issue(14)：2279-2284,6.DOI:10.3969/j.issn.2095-4344.1639
心肌支架材料在心肌梗死治疗中的应用与研究热点
Research progress of myocardial scaffolds in the treatment of myocardial infarction
摘要
Abstract
BACKGROUND: In recent years, myocardial tissue engineering has developed rapidly. By using exogenous biomaterials to simulate extracellular matrix, damaged myocardial cells can be effectively repaired or reconstructed, which has great potential value in the treatment of ischemic heart diseases such as myocardial infarction. OBJECTIVE: To review the research progress of myocardial scaffolds in the treatment of myocardial infarction. METHODS: NCBI and WanFang databases were retrieved for relevant articles published from 2008 to 2018, with the key words of "myocardial scaffold materials, myocardial infarction" in English and Chinese, respectively. RESULTS AND CONCLUSION: At present, the commonly used myocardial scaffolds are mainly natural biomaterials (including collagen/Matrigel, fibrin, chitosan, hyaluronic acid, and algae hydrochloric acid) , synthetic materials (polyester synthetic materials and nanomaterials) and composite scaffolds. Due to the complexity of cardiac environment and heart function, the selection of scaffold materials should fully take account of biocompatibility, immunogenicity, conductivity, degradation rate and susceptibility to ischemia and hypoxia. Although many scaffold designs have begun to meet many requirements, there are still many kinds of stent materials for clinical application. It is believed that with the further development of researchers and application tools, people can expect to create myocardial scaffolds close to the physiological function of the original tissue, so that the heart function can be better restored.关键词
心肌支架材料/心肌梗死/心肌组织工程/纤维蛋白/壳聚糖/天然生物材料/胶原/透明质酸/脱细胞心肌材料/人工合成材料/复合材料Key words
Myocardial Infarction/Heart, Artificial/Tissue Engineering分类
医药卫生引用本文复制引用
赵亮,邱晓娜,李霞飞..心肌支架材料在心肌梗死治疗中的应用与研究热点[J].中国组织工程研究,2019,23(14):2279-2284,6.基金项目
第二届大学生命科联赛立项课题(SKYLS017),项目负责人:赵亮 （SKYLS017）
河南省高等学校重点科研项目(17A180034),项目负责人:赵亮 （17A180034）
