中国组织工程研究2019，Vol.23Issue(15)：2409-2414,6.DOI:10.3969/j.issn.2095-4344.1154
急性脊髓损伤后48 h内外周血细胞因子的变化
Changes of cytokines in peripheral blood within 48 hours after acute spinal cord injury
摘要
Abstract
BACKGROUND: Change of microenvironment after acute spinal cord injury is the main factor causing secondary injury, so it is of great significance to investigate the changes of microenvironment after acute spinal cord injury for clinical diagnosis and treatment. OBJECTIVE: To investigate the expression levels and clinical significance of interleukin-6, brain derived neurotrophic factor, basic fibroblast growth factor, neurotrophin-3 and neurotrophin-4 in peripheral blood within 48 hours after acute spinal cord injury. METHODS: Twenty-nine patients with acute spinal cord injury admitted at the Department of Spinal Osteopathia, the First Affiliated Hospital of Guangxi Medical University from October 2016 to June 2018 were enrolled, and were divided into two groups according to American Spinal Injury Association impairment scale: complete spinal cord injury (n=11) and incomplete spinal cord injury (n=18). Thirteen patients with avascular necrosis of the femoral head were selected as controls. The expression levels of interleukin-6, brain derived neurotrophic factor, basic fibroblast growth factor, neurotrophin-3 and neurotrophin-4 in peripheral blood of 42 patients were determined by ELISA and compared. RESULTS AND CONCLUSION: The ELISA results showed that the expression levels of interleukin-6, brain derived neurotrophic factor, basic fibroblast growth factor, neurotrophin-3 and neurotrophin-4 in peripheral blood in the spinal cord injury group were significantly higher than those in the control group (P ＜ 0.05). The expression levels of all above cytokines in the complete spinal cord injury group were significantly higher than those in the incomplete spinal cord injury group (P ＜ 0.05). In summary, increased expression of interleukin-6, brain derived neurotrophic factor, basic fibroblast growth factor, neurotrophin-3, neurotrophin-4 after acute spinal cord injury indicates that it may participate in the important pathophysiological process after acute spinal cord injury.关键词
脊髓损伤/细胞因子/白细胞介素6/脑源性神经营养因子/碱性成纤维细胞生长因子/神经营养因子3/神经营养因子4Key words
Spinal Cord Injuries/Cytokines/Tissue Engineering分类
医药卫生引用本文复制引用
黄建华,曾高峰,岑忠喜,邓贵营,高云兵,宗少晖..急性脊髓损伤后48 h内外周血细胞因子的变化[J].中国组织工程研究,2019,23(15):2409-2414,6.基金项目
广西重点研发计划(桂科AB18221021),项目负责人:宗少晖 （桂科AB18221021）
广西高等学校高水平创新团队及卓越学者计划,项目负责人:宗少晖 （）
