现代医药卫生2019，Vol.35Issue(3)：342-344,349,4.DOI:10.3969/j.issn.1009-5519.2019.03.006
驱风止痛散对酵母联合腺嘌呤致痛风性肾病的作用及机制
Effect and mechanism of QuFengZhiTongSan on gouty nephropathy induced by yeast combined with adenine
摘要
Abstract
Objective To study on the protective effect and mechanism of QuFengZhiTongSanon (QFZTS) renal function in rats model of gouty nephropathy induced by yeast and adenine.Methods Sixty SD rats were randomly divided into six groups with ten rats per group:blank group, model group, allopurinol group (0.01 g/kg) , QFZTS low dose group (1.60 g/kg) , QFZTS middle dose group (3.20 g/kg) and QFZTS high dose group (6.40 g/kg).Every morning, the rats of the blank group were given pure water of equal volume, the rats of the other group were given the suspension of yeast with adenine (yeast 10 g/kg, adenine 100 mg/kg) by intragastric perfusion;Every afternoon, the rats of the blank group and model group were given pure water of equal volume, the rats of the other group were given the corresponding solution by intragastric perfusion, modeling and administration were lasted 28 days.Serum uric acid (SUA) , serum creatinine (SCr) , blood urea nitrogen (BUN) , transforming growth factor-β1 (TGF-β1) , interleukin-1β (IL-1β) of rats in each group were examined.The pathological changes in renal tissue sections of rats in each group were observed.Results Compared with blank group, the SUA and SCr levels were significantly increased in all the other groups, with statistically significant differences (P<0.01 or 0.05) ;the BUN level was significantly increased in the model group, and the difference was statistically significant (P<0.01).Compared with the model group, the levels of SUA, SCr and BUN were significantly reduced in the allopurinol group and the QFZTS groups with high, medium and low doses, and the differences were statistically significant (P<0.01 or 0.05) , with a certain dose dependence.Compared with the blank group, the TGF-β1 and IL-1βlevels were significantly increased in other groups, with statistically significant differences (P<0.01).Compared with the model group, the TGF-β1 and IL-1βlevels in the allopurinol group and the TGF-β1 level in the QFZTS group with high, medium and low doses were all decreased, and the differences were statistically significant (P<0.01).The TGF-β1 level in the high, medium and low dose groups of QFZTS were higher than that in the allopurinol group, while the IL-1βlevel in the middle and low doses of QFZTS groups were significantly higher than that in the allopurinol group, showing statistically significant differences (P<0.01).Pathologic analysis indicated that renal tubular dilatation and interstitial fibrosis were improved and inflammatory cell infiltration was reduced in allopurinol group and all doses of QFZTS groups.Conclusion QFZTS has protective effect on renal function induced by yeast and adenine in rats with gouty nephropathy.关键词
痛风/肾疾病/尿酸/血液/肌酸酐/血液/肾/病理学/驱风止痛散/痛风性肾病/炎症因子Key words
Gout/Kidney diseases/Uric acid/blood/Creatinine/blood/Kidney/pathology/QuFengZhiTongSan/Gouty nephropathy/Inflammatory cytokines分类
医药卫生引用本文复制引用
郭思彤,许立拔,梁小玲,黄菊,刘丽敏..驱风止痛散对酵母联合腺嘌呤致痛风性肾病的作用及机制[J].现代医药卫生,2019,35(3):342-344,349,4.基金项目
广西壮族自治区教育厅高校科学技术研究项目(KY2015YB059). （KY2015YB059）
