摘要
Abstract
Objective To investigate the changes of platelet 4 parameters (Plt, PCT, MPV, PDW) in patients with primary biliary cirrhosis (PBC) and their clinical significance.Methods Totally 84 cases of hospitalized patients diagnosed with PBC (PBC group) and 67 healthy subjects for routine medical check-up (control group) from January 2014 to April 2017 were selected in the study.The differences of platelet 4 parameters and biochemical indices between two groups were compared.The correlations between platelet parametersand biochemical indices, Albumin-bilirubin prognosis score model (ALBI) score of patients with PBC were analyzed.Results Compared with the control group, the Plt, PCT and ALB in PBC group were significantly decreased, while ALT, AST, ALP, GGT, GLB, TBIL, DBIL, IBIL and TBA in PBC group were evidently higher, the differences were statistically significant (P<0.01).The MPV and PDW between two groups were no differences (P>0.05).Spearman correlation analysis showed that Plt was positively correlated with ALT, AST, ALP, GGT and ALB (r=0.309, 0.294, 0.343, 0.420, 0.368, P<0.05 or 0.01) ;PCT was positively correlated with ALT, AST, ALP, GGT and ALB (r=0.306, 0.301, 0.326, 0.441, 0.387, P<0.05 or 0.01) ;Plt and PCT were negatively correlated with the prognosis ALBI score (r=-0.298, -0.312, P<0.01).Conclusion Plt and PCT are significantly decreased in patients with PBC, and significantly correlat with biochemical indices as well as ALBI score, which can provide important clues to the preliminary assessment of severity and prognosis in patients with PBC.关键词
肝硬化, 胆汁性/血小板参数/生化指标/原发性胆汁性肝硬化/血小板计数/血小板压积/ALBI评分Key words
Liver cirrhosis, biliary/Platelet parameters/Biochemical indicators/Primary biliary cirrhosis/Platelet count/Platelet hyperplasia/ALBI score分类
医药卫生
