心脑血管病防治2019，Vol.19Issue(1)：53-56,4.DOI:10.3969/j.issn.1009-816x.2019.01.003
非输血依赖性地中海贫血患者脑血管病变生物标志物S100和NSE水平观察
The Levels of S100B and NSE as Biomarkers for Cerebral Vasculopathy in Patients with Non-transfusion Dependent Thalassemia
付晓英 1朱薇 1吉莉1
作者信息
- 1. 陕西省宝鸡市中心医院检验科, 721008
- 折叠
摘要
Abstract
Objective To investigate correlation between serum S100 calcium binding protein B (S100B) or neuron-specific enolase (NSE), which were the biomarkers for cerebral vasculopathy, and transcranial doppler (TCD) detection in patients with non-transfusion-dependent thalassemia (NTDT).Methods 50 patients with NTDT (observation group) and 50 healthy subjects (control group) were enrolled.Serum S100B and NSE protein levels were detected by enzyme-linked immunosorbent assay (ELISA).Serum lactate dehydrogenase (LDH) levels were measured by enzymatic methods.Hemodynamic changes were detected by TCD.Pearson correlation analysis was used to detect the relationships between S100B and NSE and LDH and TCE blood flow parameters respectively.Results Serum S100B, NSE and LDH were significantly higher in the observed group than in the control group (all P＜0.05).There was no significant difference in the levels of serum S100B, NSE, and LDH among different NTDT phenotypes in the observation group (all P＞0.05).The mean blood flow velocity (Vm) and systolic blood flow peak velocity (Vp) of TCD were significantly higher than those of the control group (P＜0.05).The level of S100B inobserved group was positively correlated with LDH, left middle cerebral artery Vm, left middle cerebral artery Vp (P＜0.05).The level of NSE in observed group was also positively correlated with LDH, left posterior cerebral artery resistance index (RI), left posterior cerebral artery pulsatility index (PI), (P＜0.05).Conclusions The hemodynamic characteristics of TCD were related to the biomarkers of cerebral vasculopathy, the serum S100B and NSE levels.关键词
非输血依赖性地中海贫血/S100钙结合蛋白B/神经元特异性烯醇化酶/经颅多普勒Key words
Non-transfusion dependent thalassemia/S100 calcium binding protein B/Neuron specific enolase/Transcranial doppler分类
医药卫生引用本文复制引用
付晓英,朱薇,吉莉..非输血依赖性地中海贫血患者脑血管病变生物标志物S100和NSE水平观察[J].心脑血管病防治,2019,19(1):53-56,4.
