医学信息2019，Vol.32Issue(3)：65-68,4.DOI:10.3969/j.issn.1006-1959.2019.03.021
股骨头坏死骨髓IL-6表达与骨髓水肿分级的相关性研究
Correlation between Bone Marrow IL-6 Expression and Grade of Bone Marrow Edema in Osteonecrosis of Femoral Head
陈恒安 1胡海 1刘金龙 1李华 1徐祖健1
作者信息
- 1. 西南医科大学附属中医医院关节外科,四川 泸州 646000
- 折叠
摘要
Abstract
Objective To investigate the correlation between the expression of interleukin-6 (IL-6) and bone marrow edema in patients with femoral head necrosis. Methods A total of 32 patients with early femoral head necrosis treated with porous core decompression in our department of osteoarthrosis from June 2016 to December 2017 were enrolled. Preoperative combined with MRI images were divided into no bone marrow edema group, bone marrow edema level 1 group, bone marrow edema level 2 group and bone marrow edema level 3 group. All patients underwent core decompression of femoral head drilling, and bone marrow specimens of femoral head necrosis were collected through the drilling channel during operation. The expression level of IL-6 in bone marrow was detected by ELISA. The correlation between IL-6 levels in the femoral head bone marrow and ARCO staging and bone marrow edema grade was analyzed. Results Among the 42 hips, there was no bone marrow edema in 6 hips, grade 1bone marrow edema in 9 hips, grade 2 bone marrow edema in 12 hips and grade 3 bone marrow edema in 15 hips. Correlation analysis showed that there was a positive correlation between ARCO staging and bone marrow edema (r=0.567, P ＜0.05) , and there was a significant difference in bone marrow IL-6 content between different levels of bone marrow edema (F=63.963, P＜0.05) . The expression of bone marrow IL-6 in osteonecrosis was positively correlated with the grade of bone marrow edema (r =0.879, P ＜0.05) . Conclusion Bone marrow edema plays an important role in the progression of ARCO stage of femoral head necrosis, which is related to the expression of bone marrow IL-6. The expression of bone marrow IL-6 may play an important role in the progression of osteonecrosis of femoral head.关键词
股骨头坏死/骨髓水肿/IL-6/炎性细胞因子/髓芯减压术/ARCO分期Key words
Femoral head necrosis/Bone marrow edema/IL-6/Inflammatory cytokines/Core decompression/ARCO staging分类
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陈恒安,胡海,刘金龙,李华,徐祖健..股骨头坏死骨髓IL-6表达与骨髓水肿分级的相关性研究[J].医学信息,2019,32(3):65-68,4.
