摘要
Abstract
Objective To investigate the changes of peripheral blood neutrophil and lymphocyte count and erythrocyte volume distribution width (RDW) in patients with hepatitis B with the progression of hepatitis B, and the ratio of neutrophil to lymphocyte (NLR) . The relationship between RDW and hepatitis B and hepatitis B cirrhosis. Methods From August 2016 to July 2018, 162 cases were collected from the third affiliated Hospital of Anhui Medical University (Hefei first people's Hospital) , Department of Digestive Diseases, Department of infection, physical examination Center and Southern District (Binhu Hospital of Hefei) , among which 50 cases were healthy control group. There were 50 cases in hepatitis B group and 62 cases in hepatitis B cirrhosis group. Blood routine examination, liver function index, RDW, and NLR, analysis were used to analyze the difference of the corresponding values among the three groups. The liver function of patients with hepatitis B cirrhosis was assessed by Child-Pugh scoring system, and the correlation between NLR, RDW level and Child-Pugh score was analyzed. The specificity, sensitivity and accuracy of NLR and RDW in patients with hepatitis B cirrhosis were determined by (ROC) curve.Results (1) The white blood cell count, neutrophil count, lymphocyte count, ALT, AST, TBIL, ALB, PT, NLR and RDW levels of the three groups were statistically significant (P＜0.05) ;There was no significant difference in NLR and RDW between the healthy control group and the hepatitis B group (P＞0.05) . The NLR and RDW of the hepatitis B cirrhosis group were higher than those of the healthy control group and the hepatitis B group, the difference was statistically significant (P＜0.05) . (2) In the hepatitis B cirrhosis group, with the severity of liver inflammation damage, NLR levels showed a significant upward trend, and RDW also showed an increasing trend. The levels of NLR and RDW were positively correlated with Child-Pugh score in patients with hepatitis B cirrhosis (P＜0.05) . (3) Using ROC curve analysis, the AUC of NLR and RDW for diagnosis of hepatitis B cirrhosis were 0.687 and 0.816, respectively, the difference was statistically significant (P＜0.05) .When NLR and RDW had cutoff values of 2.25 and 14.25, sensitivity They were 0.581 and 0.726, respectively, and the specificities were 0.8 and 0.8, respectively. Conclusion The changes of NLR and RDW values are closely related to the development of hepatitis B and hepatitis B cirrhosis. The development of chronic hepatitis into cirrhosis and the further development of cirrhosis into decompensation will lead to a corresponding increase in NLR and RDW levels.NLR and RDW can be classified into their Child-Pugh scoring system to help predict liver function in patients with hepatitis B and to assess the degree of liver fibrosis. The AUC is used to determine the accuracy of RDW compared with NLR.关键词
NLR/RDW/乙型肝炎/乙型肝炎肝硬化Key words
NLR/RDW/Hepatitis B/Hepatitis B cirrhosis分类
医药卫生
