医学信息2019，Vol.32Issue(3)：82-85,4.DOI:10.3969/j.issn.1006-1959.2019.03.025
中性粒细胞/ 淋巴细胞比值与介入治疗中晚期非小细胞肺癌患者预后的相关性
Correlation between Neutrophil/Lymphocyte Ratio and Prognosis in Patients with Advanced Non-small Cell Lung Cancer
吴森林 1高斌1
作者信息
- 1. 安徽医科大学第三附属医院介入科,安徽 合肥 230000
- 折叠
摘要
Abstract
Objective To investigate the correlation between neutrophil/lymphocyte ratio (NLR) and prognosis in patients with advanced non-small cell lung cancer (NSCLC). Methods The clinical data of 68 patients with advanced non-small cell lung cancer who underwent interventional therapy from January 1, 2014 to January 1, 2017 were retrospectively analyzed. The preoperative NLR values were calculated and divided into high NLR group (NLR≥3.8) and low NLR group (NLR＜3.8) by establishing ROC survival curve. The progression-free survival time and total survival time of the two groups were compared, and the patients may be affected. The prognostic risk factors were analyzed by single factor and multivariate factors. Results The median overall survival was 421 d in all patients after interventional therapy. The median overall survival was 292 d in the high NLR group and 506 d in the low NLR group,the difference was statistically significant(P＜0.05); at the same time, the median progression-free survival time was 152 d in the high NLR group and 341 d in the low NLR group, the difference was statistically significant(P＜0.05). In the univariate analysis, the presence of distant metastasis, the number of interventional procedures ＜3 times and NLR ≥ 3.8 were risk factors affecting the overall survival time and progression-free survival time (P＜0.05); in the multivariate analysis, there was a distant place. Metastasis and NLR≥3.8 were independent risk factors for the overall survival time (P ＜0.05). The presence of distant metastasis, the number of interventional procedures ＜3 times and NLR≥3.8 were independent risk factors for progression-free survival (P＜0.05).Conclusion Preoperative NLR can be used as a prognostic indicator for patients with advanced NSCLC. The prognosis of NLR is poor.关键词
中性粒细胞/淋巴细胞比值/非小细胞肺癌/介入治疗/生存时间Key words
Neutrophil/lymphocyte ratio/Non-small cell lung cancer/Interventional therapy/Survival time分类
医药卫生引用本文复制引用
吴森林,高斌..中性粒细胞/ 淋巴细胞比值与介入治疗中晚期非小细胞肺癌患者预后的相关性[J].医学信息,2019,32(3):82-85,4.
