摘要
Abstract
Objective To investigate the risk factors of patients with cirrhosis complicated by portal venous thrombosis.Methods 69 patients with liver cirrhosis diagnosed in our hospital from January 2013 to January 2018 were selected, among which, 24 patients with portal vein thrombosis diagnosed by abdominal CT or abdominal ultrasound were divided into the thrombosis group, and 45 patients without thrombosis were divided into the control group.The age, sex and etiology of cirrhotic portal vein thrombosis and non-thrombotic cirrhosis were analyzed retrospectively.The D-dimer, White blood cell count (WBC) , hemoglobin (Hb) , platelets (PLT) , creatinine (Cr) , prothrombin time (PT) , activated partial thrombin time (APTT) , fibrinogen (Fib) , serum total bilirubin (TBIL) , direct bili-rubin (DBIL) , albumin (ALB) , alanine aminotransferase (ALT) , aspartate aminotransferase (AST) , gamma-glutamyltransferase (GGT) , blood ammonia concentration, history of splenectomy, portal vein width (MPV) , Thickness of spleen, esophageal vaficeal bleeding, ascites were compared between two groups.Results There were no significant difference in sex, age, causes of cirrhosis between thrombosis group and control group (P＞0.05) .The complications of esophageal variceal bleeding in the two groups were significantly different (P＜0.05) .Abdominal ultrasound or spiral CT enhanced scan showed 22 cases (91.67％) of portal vein thrombosis in thrombus group (1 case with superior mesenteric vein thrombosis, 6 cases with left/right portal vein branch, 1 case with left/right portal vein branch and 1 case with superior mesenteric vein thrombosis) .2 cases were located in left/right portal vein branch (8.33％) .There was significant difference in D-dimer and AST, ALT, ALB, PTA, PLT between the two groups (P＜0.05) .Logistic regression analysis showed that D-dimer, diameter width of portal vein and Hb were independent risk factors of portal vein thrombosis in liver cirrhosis (P＜0.05) .Conclusion The monitoring of D-dimer, hemoglobin and portal vein diameter should be strengthened in patients with liver cirrhosis, which is helpful to the early diagnosis and treatment of patients with liver cirrhosis.关键词
肝硬化/门静脉血栓/D-二聚体/门静脉内径宽度/血红蛋白Key words
Liver cirrhosis/Portal venous thrombosis/D-dimer/Portal vein width/Hemoglobin分类
医药卫生
