摘要
Abstract
Objective To observe the effect of different titration strategies in the treatment of moderate to severe cancer pain, and to select a better titration scheme for patients with severe cancer pain in the clinic. Methods A total of 120 patients with moderate to severe cancer pain who were treated in our hospital from December 2014 to June 2017 were randomly divided into group A, group B and group C, with 40 cases in each group.Patients in group A were treated with immediate release morphine tablets 5 mg q4 h as initial dose titration; patients in group B and C were treated with morphine hydrochloride sustained release tablets 10 mg and 20 mg q12 h as initial doses. After titration to significant effect, each group was changed to a sufficient amount of morphine hydrochloride sustained-release tablets for maintenance treatment. Three groups of titration time, medication compliance, major adverse reactions, and average initial day cost were observed. Results The effective time of titration in group A, B and C was (1.53±0.96) d, (4.13±1.71) d and (2.76±0.81) d, respectively, the difference was statistically significant (P＜0.05) . The medication compliance of the three groups A, B, and C were 35.00％, 90.00％, and 60.00％, respectively, the difference was statistically significant (P＜0.05) . The main adverse reactions: the incidence of constipation in group B was 13.00％, which was lower than 20.00％ in group A and 53.00％ in group C, the difference was statistically significant (P ＜0.05) . The incidence of dizziness in group B was 3.00％, Less than 23.00％ in Group A and 28.00％ in group C, the difference was statistically significant (P＜0.05) . The average initial daily expenses of the three groups A, B and C were (39.5±17.13) yuan, (55.25±27.43) yuan and (65.13±27.07) yuan, the difference was statistically significant (P＜0.05) . Conclusion The 10 mg morphine hydrochloride sustainedrelease tablets as the initial dose for the treatment of patients with moderate to severe cancer pain has a slightly longer time, but has good medication compliance, mild adverse reactions, easy management, and moderate price. It is one of the preferred titration drugs for primary hospitals.关键词
癌痛/吗啡/滴定/用药依从性/不良反应Key words
Cancer pain/Morphine/Titration/Medication compliance/Adverse reactions分类
医药卫生
