医学信息2019，Vol.32Issue(3)：128-130,3.DOI:10.3969/j.issn.1006-1959.2019.03.041
药物性肝损伤的临床分析
Clinical Analysis of Drug-induced Liver Injury
摘要
Abstract
Objective To provide drug safety information for patients and health care staff by analyzing the clinical and pathological features of DILI and related drug types. Methods The clinical data of 126 patients with DILI admitted to our hospital from June 2016 to June 2018 were retrospectively analyzed. The etiology, clinical and pathological features were analyzed. Results Chinese medicine was listed as the primary cause of126 cases of DILI, accounting for 54.14％. Most of the traditional Chinese medicine ingredients causing liver damage are Heshouwu, Tusanqi, and compound preparations for treating bone diseases, joint diseases, skin diseases, stomach diseases, leukopenia, hair loss and gynecological diseases.Western medicine was another major cause of DILI, among which anti-tuberculosis drugs were the most important cause of DILI (22.22％) , antibiotics (7.83％) and anti-thyroid drugs (3.97％) were also one of the main causes of DILI. Regardless of Chinese herbal medicine or western medicine-induced DILI, hepatocellular hepatitis was common in DILI. Conclusion The risk of medication should be clarified and drug use should be rational to reduce the occurrence of DILI. For patients with liver injury of unknown origin, pathological examination of liver tissue is recommended for further diagnosis.关键词
药物性肝损伤/中药/西药/肝细胞性肝炎/病理Key words
Drug-induced liver injury/Traditional Chinese medicine/Western medicine/Hepatocellular hepatitis/Pathology分类
医药卫生引用本文复制引用
马帅,李家斌..药物性肝损伤的临床分析[J].医学信息,2019,32(3):128-130,3.基金项目
国家自然科学基金资助项目(编号:81673242) （编号:81673242）
