摘要
Abstract
Objective To investigate the risk factors and treatment outcomes of patients with liver injury caused by anti-tuberculosis drugs. Methods The clinical data of 1033 anti-tuberculosis patients admitted to our hospital from January 2013 to January 2017 were retrospectively analyzed. Among them, 158 patients developed liver damage caused by anti-tuberculosis drugs (DILD) , and all patients were statistically analyzed. Age, history of liver disease, alcoholism, malnutrition, and sputum. Logistics multivariate regression analysis was used to analyze the risk factors and treatment outcomes of patients with DILD. Results Among 1033 anti-tuberculosis patients, 158 cases had DILD, the incidence rate was 15.30％. Age, liver disease history, alcoholism, malnutrition, and sputum positive were risk factors for DILD (P＜0.05) . After treatment of 158 patients with DILD, 150 patients (94.94％) were successfully treated and 8 patients (5.06％) were treated with failure. Conclusion Age, liver disease history, alcoholism, malnutrition, and sputum positive are risk factors for DILD. Clinically, it is necessary to monitor the drug use of dangerous people, adjust the treatment plan in time, reduce the incidence of DILD, and prompt patients to successfully complete chemotherapy.关键词
抗结核药物/肺结核/肝损伤/危险因素/治疗转归/痰菌阳性Key words
Anti-tuberculosis drugs/Tuberculosis/Liver injury/Risk factors/Treatment outcome/Sputum positive分类
医药卫生
